Coxibs and cardiovascular disease.

By G. FitzGerald. New England Journal of Medicine, 2004

926 citations recorded by the source corpus.

Subfields: Biochemistry, Organic Chemistry, Pharmacology

View Paper: https://www.semanticscholar.org/paper/e337ccc320b605457a65c7f6d517c0d084598d1e

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. G. Hansson
2. Peter Libby
3. J. Wallace
4. Bruce D. Hammock
5. J. Imig
6. John A. Arnott
7. S. Planey

In Organic Chemistry

1. G. Hansson
2. Peter Libby
3. J. Wallace
4. Bruce D. Hammock
5. J. Imig
6. John A. Arnott
7. S. Planey

In Pharmacology

1. K. Walsh
2. G. Hansson
3. Peter Libby
4. J. Wallace
5. K. Thygesen
6. Bruce D. Hammock
7. J. Imig

Citations in the corpus

• [Guidelines on the management of stable angina pectoris: executive summary]. (2006, background): “Attenuation of prostacyclin formation may predispose to elevated blood pressure, accelerated atherogenesis, and thrombosis upon plaque rupture.(145) The recent withdrawal of rofecoxib (Vioxx), a highly selective COX-2 inhibitor, was caused by findings of an increased risk of serious coronary events ”
• The immune response in atherosclerosis: a double-edged sword (2006, background): “Indeed, treatment with NSAIDs selective for cyclooxygenase-2 seems to increase the risk of thrombotic complication”
• Soluble Epoxide Hydrolase as a Therapeutic Target for Cardiovascular Diseases (2009, background): “Indeed, aspirin and non-steroidal anti-inflammatory drugs (NSAIDs), including inhibitors of COX2 (also known as PTGS2), are effective drugs that treat pain and inflammatio”
• Adiponectin protects against myocardial ischemia-reperfusion injury through AMPK- and COX-2–dependent mechanisms (2005, background): “The adverse effects of COX-2 inhibitors on cardiovascular events are thought to result from a perturbation of vascular homeostasis due to reduced synthesis of prostacycli”
• Effects of Nonsteroidal Antiinflammatory Drugs on Patient-controlled Analgesia Morphine Side Effects: Meta-analysis of Randomized Controlled Trials (2005, background): “Rofecoxib has been recently withdrawn from the market because of an increase in cardiovascular risk.(50) This risk was documented for long-term use of the drug.”
• Prostaglandins, NSAIDs, and gastric mucosal protection: why doesn't the stomach digest itself? (2008, background): “The cardiovascular toxicity of selective COX-2 inhibitors and possibly other NSAIDs has been suggested to be a consequence of the inhibition of the synthesis of prostacyclin (PGI2), which has antithrombotic properties, to an extent greater than inhibition of thromboxane (TxA2), which has prothrombot”