Cyclic dermal BMP signalling regulates stem cell activation during hair regeneration

By Maksim V. Plikus, J. Mayer, Damon de la Cruz, Ruth E. Baker, Philip K. Maini, R. Maxson, C. Chuong. Nature, 2008

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Fibroblasts: origins, definitions, and functions in health and disease (2021, background): “During the rest phase, dWAT supports hair stem cell quiescence by secreting BMP ligands (Plikus et al., 2008), whereas at the onset of new hair growth, dWAT stimulates DP fibroblast activity via PDGF ligands (Festa et al.”
Dynamics Between Stem Cells, Niche and Progeny in the Hair Follicle (2011, neutral): “Bmp4 is higher in dermis (derm) and α6+ cells as previously reported (Plikus et al., 2008).”
Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling (2011, background): “Recent data shows that during the hair cycle, mature intradermal adipocytes express BMP2 mRNA (Plikus et al., 2008), an inhibitory signal for bulge cell activity (Blanpain and Fuchs, 2006; Plikus et al., 2008).”
Epidermal homeostasis: a balancing act of stem cells in the skin (2009, background): “BMP2 and BMP4 are expressed by embryonic mesenchym”
A Two-Step Mechanism for Stem Cell Activation during Hair Regeneration (2009, positive): “The elevation of BMP inhibitory cues within the dermis in the second half of telogen (Plikus et al., 2008) is likely to impact this process, but this should affect both bulge and germ equivalently.”