Insights into SCF ubiquitin ligases from the structure of the Skp1–Skp2 complex

By B. Schulman, Andrea C. Carrano, P. Jeffrey, Zachary D. Bowen, E. Kinnucan, M. Finnin, Stephen J. Elledge, J. Harper, M. Pagano, N. Pavletich. Nature, 2000

637 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/e2d6f2b46a793f237eba13c7074878aa0f1c77a2

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. J. Harper
2. Ruth C. Lovering

In Molecular Biology

1. Stephen J. Elledge
2. M. Pagano
3. J. Harper
4. Timothy Cardozo
5. Stephen G Thomas
6. Hong Ma
7. Tai-ping Sun
8. B. Schulman

In Oncology

1. Stephen J. Elledge
2. M. Pagano
3. J. Harper

Citations in the corpus

• Sequence and structural analysis of BTB domain proteins (2005, background): “Many Skp1 sequences have low complexity insertions after A3, which are disordered in several crystal structures, followed by helix α4, which is unique to this family [23-26] (Figures 1 and 2).”
• Systematic analysis and nomenclature of mammalian F-box proteins. (2004, background): “The best understood cullin-based E3 is the SCF ubiquitin ligase (Feldman et al. 1997; Skowyra et al. 1997), which is composed of a modular E3 core containing CUL1 and RBX1 (also called ROC1), and a substrate specificity module composed of SKP1 and a member of the F-box family of proteins (Cardozo an”
• The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis. (2002, background): “…the F-box motif has been identified as the SKP1-interacting domain, and their variable protein– protein interaction domains (such as the Leu-rich repeat or WD40) function as substrate recognition domains (Bai et al., 1996; Connelly and Hieter, 1996; Li and Johnston, 1997; Schulman et al., 2000).”
• The Arabidopsis F-Box Protein SLEEPY1 Targets Gibberellin Signaling Repressors for Gibberellin-Induced Degradation (2004, background): “The F-box protein binds to Skp1 through a degenerate F-box motif, which consists of;40 amino acids in the N-terminal region (Schulman et al., 2000).”
• Structure of a -TrCP1-Skp1--Catenin Complex (2003, background): “work (Stebbins et al., 1999; Schulman et al., 2000; Zheng E2 model, the E2 active site cysteine would end up 50 Å away from the structured N- or C-terminal ends et al., 2000), we superimposed the structurally conserved portions of Skp1 and ElonginC from Cul1-Rbx1- of the -catenin peptide (Figure 4).”