Selective targeting of newly synthesized Arc mRNA to active synapses requires NMDA receptor activation.

By O. Steward, P. Worley. 2001

476 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology

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In Cellular and Molecular Neuroscience

In Molecular Biology

Citations in the corpus

Dendritic mRNA: transport, translation and function (2007, unknown): “Using in situ hybridization histochemistry, NMDA receptor-dependent localization of Arc mRNA to dendrites close to recently activated synapses in the dentate gyrus was demonstrated in vivo”
Disrupted-in-Schizophrenia-1 (DISC1) regulates spines of the glutamate synapse via Rac1 (2010, background): “We therefore examined how neuronal activity might modulate protein interactions among Kal-7, PSD-95 and DISC1 by using electroconvulsive treatment (ECT), which elicits neuronal activation in vivo”
The neuronal microRNA system (2006, background): “For example, following an electroconvulsive seizure, the newly synthesized immediate-early Arc (activity regulated cytoskeletal-associated protein) mRNA is targeted to synaptic sites in an NMDA ( N -methyl- D -aspartate)-dependent manne”
Using immediate-early genes to map hippocampal subregional functions. (2007, background): “2004), and this targeting, as well as behavioral induction, is dependent on NMDA receptor activation (Steward and Worley 2001).”
Integration of New Neurons into Functional Neural Networks (2006, background): “…which is required for spatial memory consolidation and lasting forms of plasticity (Guzowski et al., 2000) and is targeted to specific dendritic domains (Steward and Worley, 2001), provides compelling evidence that recently born neurons participate in behaviorally relevant hippocampal networks.”
The cell biology of synaptic plasticity: AMPA receptor trafficking. (2007, background): “Arc mRNA is exquisitely regulated: The transcribed message is targeted to the dendrites of neurons as they engage in information processing and storage, and it is locally translated at activated synapses (Steward & Worley 2001).”
Arc/Arg3.1 mediates homeostatic synaptic scaling of AMPA receptors. (2006, background): “1 mRNA induction and protein synthesis are regulated by neuronal activity in vivo (Steward et al., 1998; Steward and Worley, 2001).”
BDNF-induced local protein synthesis and synaptic plasticity. (2014, unknown): “…dendritic localization and translation of the Arc mRNA has been extensively studied (Messaoudi et al., 2007; Rao et al., 2006; Steward et al., 1998; Steward and Worley, 2001; Yin et al., 2002; Ying et al., 2002), and BDNF was shown to increase dendritic Arc mRNA and protein levels in cultured…”
In vivo two-photon imaging reveals a role of arc in enhancing orientation specificity in visual cortex. (2006, unknown): “…analysis revealed that Arc protein can preferentially localize to excitatory synapses in recently activated dendritic segments, while biochemical studies showed the association of Arc with protein complexes present in the postsynaptic density (Moga et al., 2004; Steward and Worley, 2001a).”