The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it

By E. Hay. Developmental Dynamics, 2005

677 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e2a4904cb17282736b563a37b85eed03e3b7b07d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. Jormay Lim
2. J. P. Thiery
3. E. Hay
4. R. Weinberg
5. Jing Yang
6. J. Massagué
7. Raghu Kalluri
8. A. Cano

In Molecular Biology

1. Jormay Lim
2. J. P. Thiery
3. E. Hay
4. R. Weinberg
5. Jing Yang
6. J. Massagué
7. Raghu Kalluri
8. M. Nieto

Citations in the corpus

• Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition (2010, background): “The reverse process, the mesenchymal to epithelial transition (MET), is essential for developmental stages such as the formation of somites and the coelomic cavity, and has been implicated as well in the growth of secondary metastatic tumors (1, 14).”
• Epithelial-mesenchymal transitions: insights from development (2012, background): “Following pioneering work from Elizabeth Hay (Greenburg and Hay, 1982; Hay, 2005), we now know that epithelial cells lose apicobasal polarity and intercellular junctions during EMT.”
• The epithelial–mesenchymal transition: new insights in signaling, development, and disease (2006, neutral): “Elizabeth Hay (Harvard University, Boston, MA), who fi rst described the EMT (Hay, 2005), illustrated the fundamental differ ences of such movement in embryogenesis (subtle/controlled) and Correspondence to Shoukat Dedhar: sdedhar@interchange.ubc.ca Abbreviations used in this paper: BMP7,…”
• Epithelial-Mesenchymal Transition in Cancer: Parallels Between Normal Development and Tumor Progression (2010, background): “Cells exhibiting a mesenchymal phenotype provide support and structure to the epithelial cells particularly through the production of an extracellular matrix and, unlike the rather confined and immobile epithelial cell, are highly motile and invasive [ 5 ].”
• Modeling tissue morphogenesis and cancer in 3D. (2007, neutral): “…are not always fixed; at specific stages of embryonic development and in some cancers, epithelial cells can undergo an epithelial-to-mesenchymal transi- tion involving the loss of cell-cell adhesions and polarity, accompanied by activation of cell migration (Hay, 2005; Thiery and Sleeman, 2006).”
• The epithelial-mesenchymal transition generates cells with properties of stem cells. (2008, neutral): “Independent of these discoveries, the epithelial-mesenchymal transition (EMT) has been described over the past decade as a cell-biological program that is required for the remodeling of cells and tissues during embryogenesis, during certain types of wound healing, and during the acquisition of malig”