Vimentin induces changes in cell shape, motility, and adhesion during the epithelial to mesenchymal transition

By Melissa G. Mendez, S. Kojima, Robert D. Goldman. The FASEB Journal, 2010

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The ins and outs of the epithelial to mesenchymal transition in health and disease. (2011, background): “Indeed, extracellular matrix proteins such as metalloproteases, Collagen I, and fibulin as well as cytoskeletal proteins such as vimentin through the Rac GTPase can promote the EMT (Lee et al. 2008, Medici & Nawshad 2010, Mendez et al. 2010, Radisky et al. 2005).”
3D Bioprinting of Heterogeneous Aortic Valve Conduits with Alginate/Gelatin Hydrogels (2012, background): “Vimentin is expressed by fibroblasts and other mesenchymal cells, while aSMA is a contractile filament primarily in SMC.(32,33) Secondary fluorescent antibodies and nuclear counterstaining (via Draq 5, 1: 1000, Biostatus) were performed for 30 min at room temperature.”
Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer (2011, background): “Inhibition of vimentin filament integrity was very recently shown to cause mesenchymal cells to adopt epithelial shape and to inhibit migration (Mendez et al., 2010).”