Generation of a functional mammary gland from a single stem cell

By Mark Shackleton, F. Vaillant, K. Simpson, J. Stingl, Gordon K. Smyth, Marie-Liesse Asselin-Labat, Li Wu, G. Lindeman, Jane E. Visvader. Nature, 2006

2,120 citations recorded by the source corpus.

Subfields: Oncology

View Paper: https://www.semanticscholar.org/paper/e294dc15b47ed3694547212ed53ff3320746ea44

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In Oncology

1. R. Weinberg
2. Zena Werb
3. Jane E. Visvader
4. K. Polyak
5. Jing Yang
6. C. Blanpain
7. Hans Clevers
8. R. Nusse

Citations in the corpus

• The epithelial-mesenchymal transition generates cells with properties of stem cells. (2008, positive): “…epithelial stem cells can form mammospheres in suspension culture (Dontu et al., 2003; Liao et al., 2007); in addition, following implantation into the mammary stromal fat pad, the murine stem cells can reconstitute an entire mammary ductal tree (Shackleton et al., 2006; Stingl et al., 2006).”
• Epithelial-Mesenchymal Plasticity: A central regulator of cancer progression (2015, background): “Following implantation of bona fide mammary stem cells, entire mammary ductal trees will grow out over a period of six to eight weeks that are indistinguishable from those formed during normal mammary gland morphogenesis (Shackleton et al., 2006; Stingl et al., 2006).”
• An integral program for tissue renewal and regeneration: Wnt signaling and stem cell control (2014, background): “How are these cycles of regrowth continually sustained? Initial transplantation (50) and subsequent lineage-tracing experiments have established that stem cells exist in the adult mammary epithelium that and they appear to be driven by Wnt signaling (51) because they are designated by Lgr5 (52–55) a”
• Keeping abreast of the mammary epithelial hierarchy and breast tumorigenesis. (2009, background): “Mouse MaSCs are highly enriched in the CD49fCD29CD24Sca1 subset (referred to as MaSCenriched) and can generate extensive ductal outgrowths upon transplantation (Shackleton et al. 2006; Sleeman et al. 2006; Stingl et al. 2006).”
• Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis. (2006, background): “These cells, which express CK14, are thought to represent the mammary stem cells (Smalley and Ashworth, 2003; Althuis et al., 2005; Shackleton et al., 2006; Stingl et al., 2006).”
• BRCA1 basal-like breast cancers originate from luminal epithelial progenitors and not from basal stem cells. (2010, background): “, 2007), but this layer also includes the mammary stem cells (Shackleton et al., 2006; Sleeman et al., 2006; Stingl et al., 2006; Taddei et al., 2008).”
• The tumor suppressor p53 regulates polarity of self-renewing divisions in mammary stem cells. (2009, background): “The calculated frequency of SCs in the normal mammary gland was 1:30,000 (Table 1 and Figure S2A), consistent with recent reports using fractionated mammary cells (Shackleton et al., 2006) (Table S1).”