Genomic responses in mouse models poorly mimic human inflammatory diseases

By Junhee Seok, H. Warren, A. Cuenca, M. Mindrinos, H. Baker, Weihong Xu, Daniel R. Richards, G. McDonald-Smith, H. Gao, Laura V. Hennessy and 29 more. Proceedings of the National Academy of Sciences of the United States of America, 2013

3,053 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/493dacfabcb17967f6f7a97e68e86e37a496f561

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Peter Libby
2. G. Hansson
3. A. Lichtman
4. Atul J. Butte
5. C. Lowell
6. T. Mayadas
7. X. Cullere
8. P. Ridker

In Oncology

1. A. Lichtman
2. G. Hansson
3. Peter Libby
4. Atul J. Butte

Citations in the corpus

• Biology-inspired Microphysiological System Approaches to Solve the Prediction Dilemma of Substance Testing (2016, neutral): “Leist and Hartung, 2013; Matthews, 2008; Olson et al., 2000; Perel et al., 2007; Hartung and Leist, 2008; Schnerch et al., 2010; Sena et al., 2010; Seok et al., 2013; van der Worp et al., 2010; Hartung, 2013).”
• Immune Effector Mechanisms Implicated in Atherosclerosis: From Mice to Humans (2013, background): “Recent work suggests that the patterns of inflammatory gene responses in inflammation differ drastically between humans and mice, with concordance at random levels (Seok et al., 2013).”
• Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework (2014, background): “29 (13) Dose limited by compound characteristics or tissue exposure not established”
• The Role of Macrophage Phenotype in Vascularization of Tissue Engineering Scaffolds (2014, neutral): “In addition, the C57BL/6 strain is a commonly used animal model for biomaterial evaluation, but macrophage behavior is likely to be different in other strains of mice or animal models, and especially in humans [86].”