Insolubility of lipids in triton X-100: physical origin and relationship to sphingolipid/cholesterol membrane domains (rafts).

By E. London, Deborah A. Brown. Biochimica et Biophysica Acta, 2000

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Co-operation of TLR4 and raft proteins in LPS-induced pro-inflammatory signaling (2014, methodology): “This approach is based on model membrane studies indicating that regions of the plasma membrane rich in saturated lipids and cholesterol are insoluble in non-ionic detergents, like Triton X-100, due to the tight packing of the lipids [70].”
Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. (2003, background): “In the past decade, sphingolipid metabolites have been revealed to modulate various cellular events including proliferation, differentiation, and apoptosis [3–5], and sphingolipids, along with cholesterol, have been shown to be required for the formation of detergent-resistant membrane microdomains ”
Separation of liquid phases in giant vesicles of ternary mixtures of phospholipids and cholesterol. (2003, background): “Given that our dark phase is rich in saturated lipids and cholesterol, it is likely equivalent to the liquid-ordered state described previously and may resemble detergent resistant phases in biological membranes (London and Brown, 2000).”
Sphingomyelin/phosphatidylcholine/cholesterol phase diagram: boundaries and composition of lipid rafts. (2003, background): “lo and ld phases, which makes it difficult to differentiate between them (London and Brown, 2000).”