Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism.

By K. Hanada. Biochimica et Biophysica Acta, 2003

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The B6 database: a tool for the description and classification of vitamin B6-dependent enzymatic activities and of the corresponding protein families (2009, background): “This subunit is not itself a PLP-dependent enzyme, but is homologous to a second subunit (LCB2) that is PLP-dependent [24].”
Potentiation of cannabinoid-induced cytotoxicity in Mantle Cell Lymphoma through modulation of ceramide metabolism (2009, background): “In the same study, increased activity of SPT was the rate-limiting step in ceramide synthesis de novo (38).”
Ghrelin: structure and function. (2005, background): “that transfer acyl groups to serine residues of target molecules have been identified, including two serine palmitoyltransferases functioning in the biosynthesis of sphingolipids in mammals (95) and a plant Ser O-acetyltransferase gene family in Arabidopsis thaliana (114).”
An overview of sphingolipid metabolism: from synthesis to breakdown (2010, background): “Therefore, a secondary function of SPT1 other than its contribution to catalytic activity may be simply to stabilize SPT2 in the ER [6].”
Discovery of the molecular machinery CERT for endoplasmic reticulum-to-Golgi trafficking of ceramide (2006, background): “condensation of L-serine and palmitoyl CoA, a reaction catalyzed by serine palmitoyltransferase (SPT), to generate 3-ketodihydrosphingosine, which is reduced to dihydrosphingosine [6].”