Endocytosis and Signaling: An Inseparable Partnership
By Pier Paolo Di Fiore, P. Camilli. 2001
392 citations recorded by the source corpus.
Far from being a simple attenuator, endocytosis is now also implicated in the initiation and propagation of signals. Signaling reciprocates by controlling endocytosis and contributing to its ability to selectively sort receptors. It appears that the quiet days of endocytosis as a relatively “stand-alone” process are over, as we expose the intricate network that connects it to actin, membrane dynamics, lipids metabolism, signaling adaptors, and transducers. Phenotypically, this is mirrored by an important role of endocytosis in proliferation, differentiation, cell survival, neurotransmission, embryogenesis, and cell fate specification. An emerging role of alterations of the endocytic machinery in diseases is therefore predicted.
Subfields: Cell Biology, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/e19dc7fc5a80af2975d7c1b0b2f424ea18d7e3b9
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Citations in the corpus
- Distinct endocytic pathways regulate TGF-β receptor signalling and turnover (2003, background): “Receptor internalization through the clathrin pathway(26,27) may be important for signalling(27,28) and SARA has been found in the PtdIns(3)P-enriched early endosome antigen-1 (EEA1)-positive endosomes(27,29,30) that are downstream of this route.”
- Genome-wide analysis of human kinases in clathrin- and caveolae/raft-mediated endocytosis (2005, methodology): “The average relative infection index (RII, the ratio of infected siRNAtreated cells to infected control-treated cells) of VSV and SV40 was consistently reduced at least threefold by (1) silencing of the aforementioned genes, (2) using established inhibitors like GTPasedeficient dynamin2 (dynamin2-K4”