Novel Carbapenem-Hydrolyzing β-Lactamase, KPC-1, from a Carbapenem-Resistant Strain of Klebsiella pneumoniae

By H. Yigit, A. Queenan, Gregory J. Anderson, A. Doménech-Sánchez, J. Biddle, Christine D. Steward, S. Albertí, K. Bush, F. Tenover. Antimicrobial Agents and Chemotherapy, 2001

1,361 citations recorded by the source corpus.

Subfields: Molecular Medicine, Pharmacology, Pollution

View Paper: https://www.semanticscholar.org/paper/e18d5469584d02e1e45748307dddb8417e9d4301

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Medicine

1. P. Nordmann
2. L. Poirel
3. F. Codjoe
4. E. Donkor
5. K. Bush
6. G. Meletis
7. A. Carattoli
8. Jung Hun Lee

In Pharmacology

1. P. Nordmann
2. L. Poirel
3. K. Bush
4. F. Codjoe
5. E. Donkor
6. D. Livermore
7. T. Strateva

In Pollution

1. F. Codjoe
2. E. Donkor
3. P. Nordmann
4. L. Poirel
5. Young Bae Kim
6. Jung Hun Lee
7. Chang-Ro Lee
8. B. Jeong

Citations in the corpus

• Carbapenemases: the Versatile β-Lactamases (2007, background): “However, the identification of plasmid-encoded IMP-1, a metallo- -lactamase in Pseudomonas aeruginosa (228), ARI-1 (OXA-23), a class D carbapenemase in Acinetobacter baumannii (157, 191), and KPC-1, a class A carbapenemase in Klebsiella pneumoniae (245), has changed the patterns of carbapenemase dis”
• Carbapenemases in Klebsiella pneumoniae and Other Enterobacteriaceae: an Evolving Crisis of Global Dimensions (2012, background): “It has been estimated that in 688 cmr.asm.org Clinical Microbiology Reviews Greek hospitals, some 10 to 15% of CPE (a bacterial population consisting mainly of KPC-2-producing K. pneumoniae strains) appear resistant by the CLSI interpretive criteria but susceptible according to EUCAST (Daikos, unpub”
• The difficult-to-control spread of carbapenemase producers among Enterobacteriaceae worldwide. (2014, background): “The IMI enzymes (IMIpenemhydrolyzing ß-lactamase) have been detected in rare isolates of Enterobacter spp. in USA [7], France [8], Croatia [9], Finland [10] and Argentina[11], and more recently a colistin-resistant ht tp :// do c. re ro .c h p Enterobacter asburiae isolate was recovered in Ireland [”
• Multiresistant Gram-negative bacteria: the role of high-risk clones in the dissemination of antibiotic resistance. (2011, background): “Endimiani A, Carias LL, Hujer AM et al. (2008) Presence of plasmid-mediated quinolone resistance in Klebsiella pneumoniae isolates possessing blaKPC in the United States.”
• Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance (2017, background): “The first qnr gene was discovered on a plasmid of K. pneumoniae isolated in 1994 in the United States (Martı́nez-Martı́nez, Pascual and Jacoby 1998).”
• The global epidemiology of carbapenemase-producing Enterobacteriaceae (2017, background): “in the United States was isolated from a patient in North Carolina.(21) This strain was identified through the Project”
• Carbapenem resistance: overview of the problem and future perspectives (2016, background): “First found in the late 1990s in the New York City area in the USA [Yigit et al. 2001], they soon spread to bordering states [Endimiani et al. 2009], Latin America [Villegas et al. 2006], and Israel [Leavitt et al. 2007].”
• Global Dissemination of Carbapenemase-Producing Klebsiella pneumoniae: Epidemiology, Genetic Context, Treatment Options, and Detection Methods (2016, background): “KPCs have been the most frequently observed class A carbapenemases since their first description in the eastern the USA in 1996 (Yigit et al., 2001).”
• Rapid spread of carbapenem-resistant Klebsiella pneumoniae in New York City: a new threat to our antibiotic armamentarium. (2005, neutral): “5 Resistant D (1) 32 32 32 8 1 Resistant E (1) 32 32 32 16 16 Resistant E (2) 32 32 32 8 2 Susceptible E (3) 32 32 32 16 8 Resistant F (1) 32 32 32 16 16 NA G (1) 32 32 32 4 2 Susceptible H (1) 32 32 32 16 4 Susceptible I (1) 32 32 32 16 16 Resistant A (1) 32 32 32 16 16 Resistant A (2) 32 32 32 16 ”