Carbapenemases in Klebsiella pneumoniae and Other Enterobacteriaceae: an Evolving Crisis of Global Dimensions

By L. Tzouvelekis, A. Markogiannakis, M. Psichogiou, P. Tassios, G. Daikos. Clinical Microbiology Reviews, 2012

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Carbapenem resistance: overview of the problem and future perspectives (2016, background): “Another significant epicentre of KPC-encoding genes may be China, even though not enough data are known to assess its actual dissemination in that country [Tzouvelekis et al. 2012].”
Antibiotic resistance and persistence—Implications for human health and treatment perspectives (2020, positive): “Carbapenemases can degrade a variety of b -lactams, including extended-spectrum cephalosporins, and many carbapenemase-genes are now carried on plasmids and have been found in Enterobacteriaceae , K. pneumoniae , P. aeruginosa and Acinetobacter baumannii (Tzouvelekis et al , 2012) (Fig 1A).”
Antimicrobial Resistance in ESKAPE Pathogens (2020, background): “SPR741 has the potential to treat a broad range of bacterial disease states, including those caused by CRE, CRPA, and CRAB strains.”
The Role of Epidemic Resistance Plasmids and International High-Risk Clones in the Spread of Multidrug-Resistant Enterobacteriaceae (2015, background): “K. pneumoniae ST258 isolates with blaKPC-2 and blaKPC-3 have significantly contributed to the worldwide distribution of this resistance trait (more details are provided in the section on high-risk clones, below) (28).”
The negative impact of antibiotic resistance. (2016, background): “and Proteus mirabilis [36,37], in centres with endemic carbapenem resistance, empiric therapy decisions now may dictate the”