Memory CD8+ T cells vary in differentiation phenotype in different persistent virus infections

By V. Appay, Rod Dunbar, M. Callan, P. Klenerman, Géraldine, A. M, Gillespie, L. Papagno, Graham, Ogg and 20 more. Nature Medicine, 2002

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Immunology of hepatitis B virus and hepatitis C virus infection (2005, background): “Indeed, HCV-specific T cells are often less differentiated than virus-specific T cells raised to other pathogen”
Lineage relationship and protective immunity of memory CD8 T cell subsets (2003, background): “Several recent studies have proposed lineage relationships between memory T cell subsets based on the phenotypic analysis of T cells from human PBMC and analyses of T cells restimulated in vitro”
Lytic Granule Loading of CD8+ T Cells Is Required for HIV-Infected Cell Elimination Associated with Immune Control (2008, neutral): “In unstimulated peripheral blood mononuclear cells (PBMCs), we and others have not detected differences in perforin or granzyme B content of HIV-specific cells between patient groups (Appay et al., 2002; Migueles et al., 2002; Sandberg et al., 2001; Zhang et al., 2003).”