Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts

By Martin Lundqvist, Johannes Stigler, G. Elia, Iseult Lynch, T. Cedervall, Kenneth A. Dawson. Proceedings of the National Academy of Sciences of the United States of America, 2008

2,902 citations recorded by the source corpus.

Subfields: Molecular Biology, Pulmonary and Respiratory Medicine, Surfaces, Coatings and Films

View Paper: https://www.semanticscholar.org/paper/e13c2c699c7d2813a70fd6eec24cc3f065434b7b

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

In Pulmonary and Respiratory Medicine

In Surfaces, Coatings and Films

Citations in the corpus

The evolution of the protein corona around nanoparticles: a test study. (2011, methodology): “and polystyrene nanoparticles, of different sizes andwith different surface properties.(1,4,5)”
The relationship between pH and zeta potential of ∼ 30 nm metal oxide nanoparticle suspensions relevant to in vitro toxicological evaluations (2009, background): “Altering the surface chemistry of nanoparticles may in turn effect how a nanoparticle binds cellular substituents such as proteins, and may affect the mechanisms by which these nanoparticles enter cells (Al-Jamal et al. 2008; Lundqvist et al. 2009).”
Understanding biophysicochemical interactions at the nano-bio interface. (2009, background): “Protein corona When nanoparticles enter a biological fluid (for example blood, plasma or interstitial fluid) they are coated with proteins that may undergo conformational changes, leading to the exposure of new epitopes, altered function and/or avidity effect”
The journey of a drug-carrier in the body: an anatomo-physiological perspective. (2012, background): “These interactions are guided by the physicochemical properties of CDCs [32], and highly influence their circulation time aswell as their deposition in tissues [33–35].”
Silica and titanium dioxide nanoparticles cause pregnancy complications in mice. (2011, background): “It has recently been shown that nanomaterials become coated with serum proteins and induce different cellular responses by binding to protein”
Effect of gold nanoparticle aggregation on cell uptake and toxicity. (2011, background): “thermodynamically favored replacement of surface-associated molecules with serum proteins.(19) The destabilization of the nanoparticle surface by both these mechanisms”
Effects of cell culture media on the dynamic formation of protein-nanoparticle complexes and influence on the cellular response. (2010, methodology): “Among these, centrifugation method has been recently recognized to provide useful information on what is usually called “hard protein corona”.(19) Therefore, once isolated by centrifugation and accurate washing, we analyzed the resulting stable protein/NP complexes by SDS-PAGE and MS analyses.”