Effect of gold nanoparticle aggregation on cell uptake and toxicity.

By Alexandre Albanese, W. Chan. ACS Nano, 2011

778 citations recorded by the source corpus.

Subfields: Biomaterials, Electronic, Optical and Magnetic Materials, Materials Chemistry

View Paper: https://www.semanticscholar.org/paper/93970948a3e079f977f8956bc5ffe1f1b5710781

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In Biomaterials

In Electronic, Optical and Magnetic Materials

In Materials Chemistry

Citations in the corpus

Quantitative characterization of nanoparticle agglomeration within biological media (2012, positive): “This is further complicated as a recent study has found that different cell types respond in different ways when exposed to aggregated nanoparticles: Albanese and Chan (2011) investigated the effect of gold nanoparticle aggregation on cellular uptake by inducing agglomeration of 15-nm gold…”
Metal Oxide Nanoparticles Induce Minimal Phenotypic Changes in a Model Colon Gut Microbiota (2015, neutral): “The addition of the NPs to the sterile food source also provided a realistic exposure scenario that can provide the possibility for representative NP transformations (Albanese and Chan, 2011; Levard et al., 2012, 2013; Lowry et al., 2012a, 2012b; Lombi et al., 2013; Reidy et al., 2013).”
Gold nanoparticles for applications in cancer radiotherapy: Mechanisms and recent advancements☆ (2017, background): “uptake, toxicity) responses [174] and the pharmacokinetic (PK) profile of the nanoparticles, but it may also lead to adverse events such as blockage of blood vessels.”
Interaction of nanoparticles with proteins: relation to bio-reactivity of the nanoparticle (2013, background): “Kinetics of uptake of the same nanomaterial has been shown to differ with different cell types [50,51].”
Endocytosis and exocytosis of nanoparticles in mammalian cells (2014, background): “It was recently suggested that the aggregates or agglomerates occur when the van der Waals attractive forces between nanoparticles are larger than the electrostatic repulsive forces (Figure 2).(11) Aggregated or agglomerated forms of nanoparticles would behave differently within biological systems t”
Protein corona fingerprinting predicts the cellular interaction of gold and silver nanoparticles. (2014, background): “LSPRi is an empirical measure of the local dielectric environment surrounding plasmonic nanoparticles.(71,72) The LSPRi for gold nanoparticles is defined as follows:”
Concepts of nanoparticle cellular uptake, intracellular trafficking, and kinetics in nanomedicine. (2019, background): “To illustrate how multifaceted and complex nanoparticle-cell interactions are, we highlight a study by Albanese and Chan that compared nanoparticle cell uptake of monodispersed gold nanoparticles with hydrodynamic diameters of 30 nm to 170 nm to corresponding nanoparticle aggregates [125].”