Mitochondria from females exhibit higher antioxidant gene expression and lower oxidative damage than males.
By C. Borrás, J. Sastre, David García-Sala, A. Lloret, F. Pallardó, J. Viña. Free Radical Biology & Medicine, 2003
624 citations recorded by the source corpus.
Subfields: Aging, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/e0a1690d8f5314642af2a1e2f54198efa0712598
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Citations in the corpus
- Progesterone receptors: form and function in brain. (2008, neutral): “In human sperm, blockade of 25-Dx with a specific”
- Glutathione Peroxidase-1 in Health and Disease: From Molecular Mechanisms to Therapeutic Opportunities (2011, positive): “Possibly, the ability of estradiol to upregulate GPx-1 transcription may contribute to the increased expression of GPx-1 in females compared to males (43, 294).”
- The role of estrogens in control of energy balance and glucose homeostasis. (2013, background): “Muscle Gpx3 expression levels are elevated in healthy females compared to males (274), and they are reduced in T2DM patients compared to healthy subjects (275).”
- Mitochondrial formation of reactive oxygen species (2003, background): “Although the mechanism behind this effect has not yet been elucidated, part of the oestrogen-dependent protection is associated with an increased mitochondrial concentration of glutathione and glutathione peroxidase activity (Borras et al. 2003).”
- Mechanistic Pathways of Sex Differences in Cardiovascular Disease. (2017, background): “Female mitochondria exhibit lower oxidative damage under stress underlain by higher antioxidant gene expression than male mitochondria (39).”
- Mitochondrial dysfunction as a cause of optic neuropathies. (2004, background): “In fact, the protective role of estrogens on oxidative stress has recently been shown in animal models (Borras et al., 2003) and has been an explanation proposed as for gender bias in LHON (Pegoraro et al.”