Exploration of the function and organization of the yeast early secretory pathway through an epistatic miniarray profile.

By Maya Schuldiner, Sean R. Collins, Natalie J. Thompson, Vladimir Denic, Arunashree Bhamidipati, Thanuja Punna, Jan Ihmels, Brenda J. Andrews, Charles Boone, Jack Greenblatt and 2 more. Cell, 2005

912 citations recorded by the source corpus.

Subfields: Biomedical Engineering, Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e08621addec4f424b314e7b86e63de9820ebb0e6

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Citations in the corpus

Differential network biology (2012, methodology): “…of genetic interactions, where both positive (alleviating) and negative (aggravating) interactions are observed along with their interaction strengths, was initially accomplished in budding yeast using the E-MAP (epistatic miniarray proﬁle) approach (Schuldiner et al , 2005; Beltrao et al , 2010).”
clusterMaker: a multi-algorithm clustering plugin for Cytoscape (2011, methodology): “Hierarchical, k-medoid, and k-means algorithms are commonly used for clustering gene expression data [1] and genetic interaction profiles [2].”
A global interaction network maps a wiring diagram of cellular function (2016, background): “In a similar regulatory relationship, positive interactions were also enriched between genes involved in mRNA decay and essential gene DAmP alleles (13), which often affect mRNA stability via disruption of their 3′ untranslated region (fig.”
Molecular mechanisms and physiological functions of mitophagy (2021, positive): “The Get1/2 complex is important for insertion of tail-anchored proteins into the ER membrane (Schuldiner et al , 2005; Schuldiner et al , 2008; Wang et al , 2014).”
Exploring genetic interactions and networks with yeast (2007, background): “For example, replacing the 3′ UTR of an essential gene with a selectable marker often leads to lower transcript levels and a resultant phenotyp”
Compact and highly active next-generation libraries for CRISPR-mediated gene repression and activation (2016, background): “, 2015) will allow for simultaneous control of several genes, facilitating dissection of cellular pathways and systematic mapping of mammalian genetic interactions (Bassik et al., 2013; Costanzo et al., 2010; Schuldiner et al., 2005).”
Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions (2017, positive): “These maps have been useful tools for predicting gene function, allowing dissection of complexes and pathways 6–10 in a range of organisms 5,7,9,11–15 .”