Recent progress in tumor pH targeting nanotechnology.

By Eun Seong Lee, Zhong-gao Gao, You Han Bae. Journal of Controlled Release, 2008

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Hydrogel nanoparticles in drug delivery. (2008, background): “Regardless of the wide range of potential applications of pH-responsive systems, cancer treatment is still considered as the golden goal for the design of pH-responsive drug delivery systems [60].”
Polymeric Micelles in Anticancer Therapy: Targeting, Imaging and Triggered Release (2010, background): “Poly(L-histidine) is the most commonly used pH-sensitive component in micellebased pH-triggered release systems since this polymer contains an imidazole ring endowing it with pH-dependent amphoteric properties (100).”
Treating metastatic cancer with nanotechnology (2011, background): “pH-sensitive and temperature-sensitive formulations have been developed to control the release of the payloa”
Effect of Zeta Potential on the Properties of Nano-Drug Delivery Systems - A Review (Part 2) (2013, background): “Electrostatic interaction between charged block copolymers and oppositely charged macromolecules has allowed the formation of core–shell nanoparticles, which are termed “polyion complex micelles” (PIC) and in this way loading efficiency will be improved [41,42].”
Targeted delivery of low molecular drugs using chitosan and its derivatives. (2010, background): “This difference in pH between tumors and normal tissue has stimulated many investigators to design novel pH-sensitive carriers [136,137].”