Cell signaling by receptor tyrosine kinases.

By Joseph Schlessinger. 2000

4,465 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Oncology

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Citations in the corpus

Kinase-targeted cancer therapies: progress, challenges and future directions (2018, background): “Principal members of RTK include 20 members including EGFR and others [61].”
Insulin signaling in osteoblasts integrates bone remodeling and energy metabolism (2010, neutral): “Receptor tyrosine kinases are often inhibited by protein tyrosine phosphatases (PTPs) (Schlessinger, 2000) and PTP1B, which dephosphorylates the insulin receptor, is a major regulator of insulin signaling in hepatocytes and myocytes (Delibegovic et al.”
How were new medicines discovered? (2011, background): “For example, receptor tyrosine kinase activation requires conformational changes that are facilitated by ligand bindin”
Cell-signalling dynamics in time and space (2006, background): “p p =     − + + − + + = − − 2 2 2 2 2 , ) 1 ( ) 1 ( ) 1 ( ) 1 ( ) ( ) ( α α α α α α α α α α α (4)”
RTK and TGF-β signaling pathways genes in the sea urchin genome (2006, background): “Mutations in RTK genes are directly responsible for a variety of malignancies or are closely associated to these diseases (Schlessinger, 2000).”
Cytoreductive antitumor activity of PF-2341066, a novel inhibitor of anaplastic lymphoma kinase and c-Met, in experimental models of anaplastic large-cell lymphoma (2007, background): “There now exists a strong precedent in clinical oncology that robust efficacy can be obtained with inhibitors directed toward oncogenic tyrosine kinases that are genetically dysregulated in selected tumors (1, 2).”
Liquid-Liquid Phase Separation in Disease. (2019, background): “These findings are highly relevant for cancer because the TCR is similar to ligand-activated receptor tyrosine kinases (RTKs) that are often mutated in cancer cells (95).”
Signaling mechanisms of the epithelial-mesenchymal transition (2014, background): “Growth factor binding to RTKs induces receptor dimerization and trans-phosphorylation of the intracellular domains, thus transducing the signal to intracellular cascades (139).”
Feedback regulation of EGFR signalling: decision making by early and delayed loops (2011, background): “Readers interested in broadening the picture are referred to two recent review”
Lectin Receptor Kinases in Plants (2002, background): “This C-terminal domain is considered as a regulatory region susceptible to interact with signaling proteins (see Schlessinger, 2000, and Hubbard and Till, 2000 for review).”
The ErbB/HER family of protein-tyrosine kinases and cancer. (2014, background): “The ErbB/HER protein-tyrosine kinases, which include the epiermal growth factor receptor, are among the most studied cell ignaling families in biology [1].”