Endogenous DNA double-strand breaks: Production, fidelity of repair, and induction of cancer

By M. Vilenchik, A. Knudson. Proceedings of the National Academy of Sciences of the United States of America, 2003

697 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/e057a6f84cfd6b917b3384cceeb234421521d2bb

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Citations in the corpus

DNA damage and its links to neurodegeneration (2014, positive): “…as follows – 200 cytosine deaminations, 3000 guanine methylations, 10000 spontaneous depurinations, 10000–100000 oxidative lesions, 10000 single strand breaks, and 10–50 double strand breaks (Ames et al., 1993; Haber, 1999; Lindahl, 1993; Nakamura et al., 1998; Vilenchik and Knudson, 2003).”
CRISPR-engineered T cells in patients with refractory cancer (2020, background): “A complication of assays to assess repair by nonhomologous end joining (NHEJ) is that DNA double-strand breaks are formed spontaneously during cell division at high rates in the absence of added nucleases (36), which can”
Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats (2011, background): “It is estimated that at least 5000 singlestranded DNA breaks occur during a single cell cycle as a result of ROS production [10,11].”
γ-H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin (2008, background): “Thus, g-H2AX has the potential of developing to a useful predictor of cellular radiosensitivity to killing and may find application in the clinic during treatment of human tumors with ionizing radiation, in the evaluation of interindividual variations in radiosensitivity (141,142), in the analysis o”
Molecular Mechanisms of Ultraviolet Radiation-Induced DNA Damage and Repair (2010, background): “As a result of multiple interactions with a number of repair proteins XRCC1 plays a crucial role in the coordination of BER and SSB repair [189].”