Liver, muscle, and adipose tissue insulin action is directly related to intrahepatic triglyceride content in obese subjects.

By K. Korenblat, E. Fabbrini, B. S. Mohammed, S. Klein. Gastroenterology, 2008

620 citations recorded by the source corpus.

Subfields: Endocrinology, Diabetes and Metabolism, Epidemiology, Physiology

View Paper: https://www.semanticscholar.org/paper/583ea7ff89ae3ebd20b01708b92228e15c0f7b02

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Endocrinology, Diabetes and Metabolism

1. André Tchernof
2. S. Klein
3. J. Despres
4. A. Okunade
5. B. Patterson
6. C. Day
7. S. Bellentani
8. Ralph DeFronzo

In Epidemiology

1. C. Day
2. André Tchernof
3. S. Bellentani
4. S. Klein
5. V. Ratziu
6. A. Okunade
7. B. Patterson
8. Giulio Marchesini

In Physiology

1. J. Despres
2. A. Chait
3. Laura J. den Hartigh
4. Ralph DeFronzo
5. Melania Gaggini
6. Amalia Gastaldelli
7. Emma Buzzigoli
8. André Tchernof

Citations in the corpus

• Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity (2009, methodology): “Adipose tissue and skeletal muscle insulin sensitivity were assessed as the relative decrease in palmitate Ra during stage 1 and the relative increase in glucose Rd during stage 2 of the euglycemic-hyperinsulinemic clamp procedure, respectively (9).”
• Non-Alcoholic Fatty Liver Disease (NAFLD) and Its Connection with Insulin Resistance, Dyslipidemia, Atherosclerosis and Coronary Heart Disease (2013, positive): “Adipose tissue insulin resistance is quantified using the index Adipo-IR (FFA × INS) [7,23] that reflects the inability of insulin to suppress peripheral lipolysis.”
• Quantitative Assessment of Liver Fat with Magnetic Resonance Imaging and Spectroscopy (2011, background): “[5] (below) is probably adequate to mitigate the effects of T2*.”
• Adipose Tissue Distribution, Inflammation and Its Metabolic Consequences, Including Diabetes and Cardiovascular Disease (2020, background): “Other conditions associated with visceral adiposity, such as hepatic fat content, may instead drive insulin resistance (292, 399).”
• Increased de novo Lipogenesis is a Distinct Characteristic of Individuals with Nonalcoholic Fatty Liver Disease (2013, neutral): “The role of insulin resistance appears to be central to the development of NAFLD, particularly when it occurs in multiple tissues.(6,8) The present data join the established”
• Pathophysiology of human visceral obesity: an update. (2013, background): “Overall, there is solid evidence that liver fat content, being so proximal to the plasma cardiometabolic risk profile, is closely related to overproduction of triglyceride-rich lipoproteins and glucose, contributing to the impaired glucose homeostasis/dyslipidemic state found in viscerally obese pat”
• A position statement on NAFLD/NASH based on the EASL 2009 special conference. (2010, background): “Therefore the hepatic fat content could identify IR patients who might not be detected by a standard clinical evaluation [77].”
• Insulin resistance drives hepatic de novo lipogenesis in nonalcoholic fatty liver disease. (2019, methodology): “16 infused glucose during the last 20 min of the HEC procedure (1).”