The Hedgehog Pathway Promotes Blood-Brain Barrier Integrity and CNS Immune Quiescence

By Jorge I Alvarez, A. Dodelet-Devillers, Hania Kebir, I. Ifergan, Pierre J. Fabre, S. Terouz, Mike Sabbagh, K. Wosik, L. Bourbonnière, Monique Bernard and 4 more. Science, 2011

781 citations recorded by the source corpus.

Subfields: Molecular Biology, Neurology, Surgery

View Paper: https://www.semanticscholar.org/paper/e02eebc3387e7cea89270be0a0ba643757a1d2c9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. M. Sofroniew
2. J. Burda
3. A. Prat
4. N. Ferrara
5. I. Galea
6. Michael A. Wheeler
7. R. Daneman
8. Rakesh K. Jain

In Neurology

1. J. Burda
2. M. Sofroniew
3. F. Quintana
4. Alexander M. Bernstein
5. Michael A. Wheeler
6. M. Linnerbauer
7. A. Prat
8. N. Ferrara

In Surgery

1. I. Galea

Citations in the corpus

• The blood–brain barrier in systemic infection and inflammation (2021, background): “maintain a transcriptional program including all three molecular components of tight junctions [72].”
• Astrocyte roles in traumatic brain injury (2015, background): “In this regard, astrocyte released molecules that act on endothelia to reduce blood brain barrier permeability after CNS injury include Sonic hedge hog (Shh) (Alvarez et al., 2011; Alvarez et al., 2013) and retinoic acid (Mizee et al., 2014).”
• Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease. (2012, background): “In the healthy CNS, these proteins are confined to the vasculature, and their leakage into the parenchyma has been widely used as an endogenous marker of BBB disruption (8, 11, 17).”
• The blood-brain barrier. (2015, background): “(C) Magnified EM of ECs depicting a relationship among ECs (with tight junctions [TJ]), PCs, basement membranes (BMs), and astrocyte endfeet (AE).”
• Functional morphology of the blood-brain barrier in health and disease (2018, neutral): “Additionally, ACs secrete sonic hedgehog (Shh), retinoic acid (RA) and angiopoietin-1 (Ang-1), all key factors that induce or support barrier properties of brain ECs [5, 43].”
• Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation (2012, positive): “Sonic hedgehog (Shh), another well-known morphogen protein, acting through its membrane receptors Patched1 (Ptch1)/Smoothened (Smo), was also recently shown to control BBB differentiation and to maintain the immune privilege of the CNS by inhibiting the endothelial production of chemokines and expre”
• Astrocyte crosstalk in CNS inflammation (2020, background): “For example, astrocytes promote BBB stability via the production of sonic-hedgehog (Shh) (Alvarez et al., 2011), a morphogen that has numerous roles during development and adulthood (Fuccillo et al.”
• Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and CNS inflammation via the aryl hydrocarbon receptor (2016, neutral): “pSOCS:AhR(1) forward, 5′CCAGCTCCCTACCTGTTTGA-3′, and reverse, 5′-GGAATGGAGCGGACAGGA-3′; pSOCS2:AhR(2) forward, 5′-ATGAGTCAACACGTCCCAGA-3′, and reverse, 5′CTGCACACTCTCGTTTTGGG-3′, pSOCS2:AhR(3), forward, 5′TGGCAAAGTCTCTCGCAGA-3′, and reverse, 5′-TGCTCGGGGTTAAATGGTAC-3′.”