Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines
By A. Proudfoot, Tracy M. Handel, Z. Johnson, E. Lau, P. LiWang, I. Clark‐Lewis, F. Borlat, T. Wells, M. Kosco-Vilbois. Proceedings of the National Academy of Sciences of the United States of America, 2003
862 citations recorded by the source corpus.
Subfields: Immunology and Allergy, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/e0121e6cca4bdda4124ee5f8fee4e338ecfa375b
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Citations in the corpus
- Pathophysiology of Myocardial Infarction (2015, neutral): “chemokine/chemokine receptor pairs orchestrates recruitment of leukocyte subsets with distinct properties (89, 268, 299).”
- Monocyte recruitment during infection and inflammation (2011, background): “In support of this model, monocyte recruitment is impaired by amino acid substitutions in CCL2 that prevent dimerization or association with glycosaminoglycan”
- Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells. (2004, background): “Other chemokines may act sequentially and divide the roles in induction of firm adhesion and transmigration (114) or use two alternative receptors for these two steps, as apparently happens with CCL5, which signals to monocytes through CCR1 and CCR5 to induce adhesion and transmigration, respectivel”
- Heparan sulfate proteoglycans. (2011, background): “Binding of chemokines to HSPGs allows their local retention, protection from degradation (Sadir et al. 2004), activation by oligomerization (Proudfoot et al. 2003), and presentation to leukocytes (Handel et al. 2005).”
- Demystifying Heparan Sulfate–Protein Interactions (2014, background): “With very few exceptions, all chemokines have a strong tendency to oligomerize, and oligomerization plays an essential role in chemokine biology (44, 66, 67).”
- The role of CXC chemokines and their receptors in cancer. (2008, background): “[13] A.”
- Interconversion between two unrelated protein folds in the lymphotactin native state (2008, background): “GPCR activation on a target leukocyte stimulates extravasation from the bloodstream and migration toward the chemokine source (13, 14).”
- Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, background): “CCL2 dimerizes and binds to extracellular matrix glycosaminoglycans, thus establishing a stable gradient for CCR2+ inflammatory monocytes (87).”
- Structure of CC Chemokine Receptor 5 with a Potent Chemokine Antagonist Reveals Mechanisms of Chemokine Recognition and Molecular Mimicry by HIV (2017, background): “Similarly, CCL5 40s-loop residues K45 and R47 were demonstrated to be important for CCR5 activation (Martin et al., 2001) and chemotaxis (Proudfoot et al., 2003).”
- The chemokine system in innate immunity. (2015, background): “The DARC/chemokine complex is then transcytosed across the endothelial cell and ultimately presented on the luminal surface, where the bound chemokine is able to activate and promote immune cell transmigration (Proudfoot et al. 2003; Pruenster et al. 2009).”