Cohesins functionally associate with CTCF on mammalian chromosome arms.

By Vania Parelho, Suzana Hadjur, Mikhail Spivakov, M. Leleu, S. Sauer, H. C. Gregson, A. Jarmuz, C. Canzonetta, Zoe Webster, T. Nesterova and 6 more. Cell, 2008

944 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/dfc0d49118a69ed9d8c5c675d720353814f70f9c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

Citations in the corpus

Targeted degradation of CTCF decouples local insulation of chromosome domains from genomic compartmentalization (2017, positive): “However, given that most CTCF binding events overlap with Cohesin enrichment by ChIP-seq (Parelho et al., 2008; Rubio et al., 2008; Wendt et al., 2008), we performed a meta-analysis by aggregating our Hi-C signal at CTCF/Cohesin bound loops, as previously detected by high-resolution HiChip for…”
Transcriptional Regulation and its Misregulation in Disease (2013, positive): “Thus, cohesin is thought to have roles in transcription activation at some genes and in silencing at others (Dorsett, 2011; Hadjur et al., 2009; Parelho et al. 2008; Phillips and Corces, 2009; Schmidt et al., 2010; Seitan and Merkenschlager, 2012; Wendt et al. 2008).”
Architecture of the human regulatory network derived from ENCODE data (2012, background): “Overall,thePPMshows wellknownsetsofco-associatedtranscriptionfactors,suchasFOS– JUN(theAP1complex 30,31 ) and CTCF–RAD21–SMC3 (the cohesion complex 32,33 ), as well as many novel co-associations, such as CHD2– ZBTB33, EGR1–ZBTB7A and CTCF–ZNF143–SIX5 (Supplementary Information, section C3.”
A decade of 3C technologies: insights into nuclear organization. (2012, background): “Interestingly, genes that are activated or poised for transcription can dissociate from the nuclear lamina (Peric-Hupkes et al. 2010).”
Enhanced Regulatory Sequence Prediction Using Gapped k-mer Features (2014, background): “In this dataset, most of these long binding sites arise in ChIPseq data sets for CTCF and members of the cohesin complex (RAD21, SMC3) known to be physically associated with CTCF [19].”
Enhancer function: new insights into the regulation of tissue-specific gene expression (2011, positive): “However, the mechanism underlying their transcription regulatory function only became evident recently when cohesins were shown to interact with CCCTC-binding factor (CTCF”
Epigenetic control of T-helper-cell differentiation (2009, background): “CTCF co-localizes with cohesins, which contributes to the CTCF-dependent insulator function and perhaps to CTCF-mediated chromatin loopin”
Architectural protein subclasses shape 3D organization of genomes during lineage commitment. (2013, positive): “In the case of cohesin, a protein with a well-known architectural function during mitosis, recent reports have suggested a critical mechanistic role in insulation based on the finding that CTCF and cohesin colocalize across the genome at thousands of loci (Parelho et al., 2008; Wendt et al., 2008).”