The evolution of lncRNA repertoires and expression patterns in tetrapods

By A. Necsulea, M. Soumillon, Maria Warnefors, A. Liechti, Tasman Daish, U. Zeller, J. Baker, F. Grützner, Henrik Kaessmann. Nature, 2014

966 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/dfb508e093f1f5718e67221f4e43ccf693ace384

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Citations in the corpus

Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism (2016, neutral): “2l, m) and most that have been evaluated across species exhibit primate-specific expression patterns in the brain 11 , which we confirm for several transcripts (Supplementary Information, Extended Data Fig.”
CRISPRi-based genome-scale identification of functional long non-coding RNA loci in human cells (2016, positive): “lncRNAs appear to have originated much later than protein-coding genes, consistent with their not playing generic housekeeping roles (3, 56).”
Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder (2018, positive): “As a subset of lncRNAs are thought to function by repressing mRNA targets (72), we applied csuWGCNA (73) to identify potential regulatory relationships (21).”
NONCODE 2016: an informative and valuable data source of long non-coding RNAs (2015, background): “NONCODE has added six new species, mainly from multi-species RNA-Seq data (37,38).”
Roles, Functions, and Mechanisms of Long Non-coding RNAs in Cancer (2016, background): “However, it should be noted that several lncRNAs are ultra-conserved in DNA sequence—3% of lncRNAs appear to have originated more than 300 million years ago and can be found from organisms ranging from Xenopus and chicken to man [33].”
Interpretable RNA Foundation Model from Unannotated Data for Highly Accurate RNA Structure and Function Predictions (2022, methodology): “Here we obtain their evolutionary relationship from an evolutionary study of lncRNA repertoires and expression patterns [41].”
The Landscape of Long Noncoding RNAs in the Human Transcriptome (2015, neutral): “Protein coding (21,313) Read-through (8,020) a b”
The rise of regulatory RNA (2014, background): “This suggests that more sophisticated phenotypic screens may be required, especially in relation to cognitive function, since most mammalian lncRNAs are expressed in the brain 198 and many are mammal-or primate-specific 242,243 .”
The Landscape of long non-coding RNA classification (2015, positive): “As an indication of their functionality, expression analysis of 11 tetrapod species found 2,508 lincRNAs expressed in at least three species and originating more than 90 million years ago [71].”