Postsynaptic depolarization requirements for LTP and LTD: a critique of spike timing-dependent plasticity

By John E. Lisman, Nelson Spruston. 2005

285 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Electrical and Electronic Engineering

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Citations in the corpus

Reinforcement learning with modulated spike timing dependent synaptic plasticity. (2007, background): “As we noted in our Methods section, and as emphasized in a recent review (Lisman and Spruston 2005), a number of studies report that low frequency pairing of individual pre-and postsynaptic spikes does not suffice to induce synaptic plasticity .”
Frontiers in Synaptic Neuroscience Synaptic Neuroscience (unknown): “One builds up BCM from STDP by making the (not uncontested) assumption that spike timing is more fundamental to plasticity than spike rate (Lisman and Spruston, 2005).”
Plasticity of Cortical Excitatory-Inhibitory Balance (2015, background): “An increase in firing rate and STDP paradigms are effective experimental means for changing synaptic strength, but long-term synaptic modifications and changes to sensory responses can also be induced in the absence of postsynaptic spiking (Gambino et al. 2014, Lisman & Spruston 2005).”
The tempotron: a neuron that learns spike timing–based decisions (2006, background): “A crucial role of the postsynaptic voltage in the induction of long-term plasticity has been demonstrated in several preparation”
Neuromorphic Electronic Circuits for Building Autonomous Cognitive Systems (2014, methodology): “This is the condition for linearity, under which the circuit starts to behave as a first order low-pass filter, as described in Section II.”
Requirement of dendritic calcium spikes for induction of spike‐timing‐dependent synaptic plasticity (2006, background): “Together, these findings indicate that active dendritic mechanisms are likely to play an important role in determining both the efficacy, as well as the time window, for STDP induction (Lisman & Spruston, 2005).”
The spike timing dependence of plasticity (2012, background): “…derive from concerns that postsynaptic spikes and spike timing are relatively minor factors for plasticity under natural network conditions, and therefore that STDP is not a particularly accurate or useful description of natural plasticity (Lisman and Spruston, 2005, 2010; Shouval et al., 2010).”
Spike-Timing-Dependent Plasticity: A Comprehensive Overview (2012, background): “This is an important criticism – which the authors have made before (Lisman and Spruston, 2005) – that researchers in the STDP field should take to heart and try to address.”
The Convallis Rule for Unsupervised Learning in Cortical Networks (2013, background): “It is important to remember however that STDP is not a fundamental description of synaptic plasticity, but simply an experimental observation that describes how synapses respond to one particular stimulus of temporally offset spike pairings [3–6].”
A History of Spike-Timing-Dependent Plasticity (2011, background): “Although some controversy remains regarding the general relevance of STDP as a cellular learning paradigm (Lisman and Spruston, 2005), this preservation of timing sensitivity in cellular learning across millions of years of evolution would seem to suggest that STDP is not just relevant but actually…”
Reactivation of experience-dependent cell assembly patterns in the hippocampus (2008, background): “Another line of work has shown that dendritic depolarization is sufficient for plasticity in CA1 cells; back-propagating action potentials (needed for STDP) are not require”
Connectivity reflects coding: a model of voltage-based STDP with homeostasis (2010, background): “However, the question of whether STDP is more fundamental than frequency-dependent plasticity or voltage-dependent plasticity rules has not been resolved despite an intense debat”
Triplets of Spikes in a Model of Spike Timing-Dependent Plasticity (2006, background): “…such as calcium concentration (Malenka et al., 1988; Lisman, 1989; Lisman and Zhabotinsky, 2001; Shouval et al., 2002) or postsynaptic membrane potential (Rao and Sejnowski, 2001; Sjo¨stro¨m et al., 2001; Lisman and Spruston, 2005) play an important role in triggering potentiation or depression.”
A Voltage-Based STDP Rule Combined with Fast BCM-Like Metaplasticity Accounts for LTP and Concurrent “Heterosynaptic” LTD in the Dentate Gyrus In Vivo (2015, unknown): “This can be explained by the failure of the passively conducted APs to breach the - 37 mV threshold for STDP in the outer molecular layer , in contrast to what hap - pens in the middle molecular layer ( Fig 7B ) .”
Synaptic Consolidation: From Synapses to Behavioral Modeling (2015, background): “The synaptic weight, which is “visible” in electrophysiological experiments, can be related to the number and phosphorylation state of AMPA receptors (Lisman and Spruston, 2005), as well as the release probability of presynaptic vesicles (Tsodyks et al., 1998).”
Dendritic excitability and synaptic plasticity. (2008, unknown): “It follows that axonal spike output need not be inextricably linked to the induction of plasticity (433).”