Reactivation of experience-dependent cell assembly patterns in the hippocampus

By J. O’Neill, Timothy J. Senior, Kevin Allen, J. Huxter, J. Csicsvari. 2008

313 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience

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In Cellular and Molecular Neuroscience

In Cognitive Neuroscience

Citations in the corpus

Hippocampal replay in the awake state: a potential physiological substrate of memory consolidation and retrieval (2011, background): “In addition, novelty increases the reactivation of neurons associated with new experiences during subsequent slee”
Distinct hippocampal-cortical memory representations for experiences associated with movement versus immobility (2017, unknown): “Lastly, we note that the independent reactivation of movement- and immobilityassociated representations could arise from a Hebbian mechanism that separates continuous representations based on the proportion of non-coincident firing between the activity of two cells (O’Neill et al., 2008).”
The content of hippocampal “replay” (2018, background): “Indeed, several studies have found that representation of novel versus familiar environments is elevated in replay (Kudrimoti et al., 1999; McNamara et al., 2014; O’Neill et al., 2008).”
Automatic Recall Machines: Internal Replay, Continual Learning and the Brain (2020, background): “In the brain, experiences associated with higher surprise and thus representational change also increase the intensity of replay during and after the experience [Cheng and Frank, 2008, O’Neill et al., 2008].”
Hippocampal sharp wave‐ripple: A cognitive biomarker for episodic memory and planning (2015, background): “Three further studies show that SWP-R-associated replay occurs more frequently after exploration of a novel rather than a familiar environment (O’Neill et al., 2008; Cheng and Frank, 2008; Grosmark et al., 2014).”
Rewarded Outcomes Enhance Reactivation of Experience in the Hippocampus (2009, unknown): “These studies have shown that reactivation during sleep reflects the structure of previous awake experience (Wilson and McNaughton, 1994), and the amount that two cells fire together during SWRs in sleep depends on the amount that the two cells fire together during prior experience (O’Neill et al., ”
Sleep and synaptic renormalization: a computational study. (2010, background): “A plausible 109 scenario is that reactivation frequency may reflect the strength of the underlying synaptic traces (Feller 110 1999; Sutherland & McNaughton 2000; O'Neill et al. 2008), though direct evidence is lacking.”
Network dynamics underlying the formation of sparse, informative representations in the hippocampus (2008, unknown): “This complements previous work showing that CA1 cells are reactivated together both during and after a novel experience (Cheng and Frank, 2008; O’Neill et al., 2008).”
Revealing neuronal function through microelectrode array recordings (2015, unknown): “For example, repetition of activation patterns (Abeles and Gerstein, 1988; Sun et al., 2010) can be considered as memory traces, replayed by the appearance of a similar stimulus or due to internal processes that occur, e.g., during sleep (O’Neill et al., 2008; Abel et al., 2013).”
Hippocampal Offline Reactivation Consolidates Recently Formed Cell Assembly Patterns during Sharp Wave-Ripples (2016, background): “Consistent with a role for reactivation in memory consolidation, co-firing patterns associated with spatial novelty or rewarded learning are reactivated more strongly (O’Neill et al., 2008; Singer and Frank, 2009; McNamara et al., 2014), and electrical disruption of hippocampal SWRs during sleep imp”