Caco-2 monolayers in experimental and theoretical predictions of drug transport.

By Per Artursson, Katrin Palm, K. Luthman. Advanced Drug Delivery Reviews, 2001

965 citations recorded by the source corpus.

Subfields: Oncology, Pharmaceutical Science

View Paper: https://www.semanticscholar.org/paper/df59c40f0ac7d94d7530fc49cd03e0f2751a8536

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In Oncology

In Pharmaceutical Science

Citations in the corpus

Guidelines for the welfare and use of animals in cancer research (2010, methodology): “…Carlile, 1997; Riley et al, 2002) Passive diffusion/cell uptake PAMPA (Ottaviani et al, 2006) Cell and gut permeability predictions Caco-2 cells (Artursson et al, 2001) Blood–brain barrier permeability predictions hCMEC/D3 cells (Poller et al, 2008) Drug–drug interactions (e.g., CYP450) Human…”
The blood-brain barrier: an engineering perspective (2013, methodology): “The transwell assay is widely used to study absorption of orally administered molecules in the intestine (Artursson, 1991; Artursson et al., 2001; Stenberg et al., 2001; Hubatsch et al., 2007).”
Classification of orally administered drugs on the World Health Organization Model list of Essential Medicines according to the biopharmaceutics classification system. (2004, methodology): “However, absolute values reported can vary by orders of magnitude among laboratories [3] and unless the methodology is validated according to the FDA biowaiver Table 3 Classification of orally administered drugs on the WHO model list of Essential Medicines according to the BCS: drugs with inconclusi”
TEER measurement techniques for in vitro barrier model systems (2015, background): “Caco-2 cells are often used for studying nutrient and drug transport as they provide the main routes of substance transport from (1) the paracellular route through tight junction complexes; (2) the passive transcellular route through the bodies of epithelial cells; (3) the active, carrier-mediated p”
Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers (2007, background): “As a consequence, the proper reconstitution of a human differentiated epithelial cell monolayer in vitro allows the prediction of oral drug absorption in human”