Determination of drug permeability and prediction of drug absorption in Caco-2 monolayers
By I. Hubatsch, E. Ragnarsson, Per Artursson. Nature Protocols, 2007
1,358 citations recorded by the source corpus.
Subfields: Catalysis, Mechanical Engineering, Water Science and Technology
View Paper: https://www.semanticscholar.org/paper/c54a5af88c8e684493e4301557c5862bee4ef7ee
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In Mechanical Engineering
In Water Science and Technology
Citations in the corpus
- Controlled Drug Delivery Systems: Current Status and Future Directions (2021, background): “The majority of drugs that are absorbed via active transport share a similar structure with endogenous substances such as ions, vitamins, sugars and amino acids [30,33].”
- Coexistence of passive and carrier-mediated processes in drug transport (2010, background): “Typical drugs used for these investigations (the number in the parentheses is oral Fa in humans): acebutolol (80–90), acetaminophen (80), acetylsalicylic acid (84–100), acyclovir (20–23), allopurinol (90), alprenolol (93–96), amiloride (50), ampicillin (62), antipyrine (97), atenolol (50–54), aztreo”
- Elucidation of the Impact of P-glycoprotein and Breast Cancer Resistance Protein on the Brain Distribution of Catechol-O-Methyltransferase Inhibitors (2017, methodology): “The apparent permeability coefficient (Papp) of compounds (in centimeters/ second) was calculated using the following equation (Hubatsch et al., 2007):”
- The blood-brain barrier: an engineering perspective (2013, methodology): “The concentration of solute on the input side cin (mol cm−3) and the area A (cm2) of the monolayer are the input parameters, and the concentration of solute on the output side is measured as a function of time.”