Pravastatin Treatment Increases Collagen Content and Decreases Lipid Content, Inflammation, Metalloproteinases, and Cell Death in Human Carotid Plaques: Implications for Plaque Stabilization

By M. Crisby, Gunilla Nordin-Fredriksson, P. Shah, J. Yano, Jenny Zhu, J. Nilsson. Circulation, 2001

1,068 citations recorded by the source corpus.

Subfields: Immunology, Pulmonary and Respiratory Medicine, Surgery

View Paper: https://www.semanticscholar.org/paper/df40aa045f88e5e28005369b74b007b0dc67491a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. Peter Libby
2. P. Ridker
3. Alberico L. Catapano
4. J. Bentzon
5. G. Hansson
6. I. Tabas

In Pulmonary and Respiratory Medicine

1. I. Graham
2. Børge G. Nordestgaard
3. J. Bentzon
4. P. Ridker

In Surgery

1. Peter Libby
2. I. Graham
3. P. Ridker
4. Jan Boren
5. M. Chapman
6. Marja-Riitta Taskinen
7. Alberico L. Catapano
8. Børge G. Nordestgaard

Citations in the corpus

• Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel (2020, background): “content, inflammatory cells, metalloprotease activity, and cell death, all of which favour plaque stabilization.(17) Furthermore, several early studies involving quantitative coronary angiography without(269) or with intravascular ultrasound(18) demonstrated modest but significant”
• Stabilization of atherosclerotic plaques: New mechanisms and clinical targets (2002, background): “Despite the limited number of subjects and the difficulties regarding sampling, one recent clinical study showed increased collagen in human carotid endarterectomy specimens after administration of pravastatin, supporting this possibilit”
• In vivo 18F-fluorodeoxyglucose positron emission tomography imaging provides a noninvasive measure of carotid plaque inflammation in patients. (2006, background): “Crisby et al. (20) demonstrated that plaques taken from symptomatic patients subjected to modest lipid lowering (40 mg/day pravastatin for 3 months) are less inflamed than plaques from patients that did not receive lipid-lowering therapy (15.0 (cid:5) 10.2% vs. 25.3 (cid:5) 12.5% CD68 staining; p (ci”
• Simvastatin attenuates plaque inflammation: evaluation by fluorodeoxyglucose positron emission tomography. (2006, background): “Crisby et al. ( 22 ) have demonstrated that patients after 3-month statin treatment had less lipid and oxidized LDL-C and fewer macrophages and T cells in the endatherectomized carotid samples compared with patients without statin.”
• Anti-Inflammatory Effects of Statins: Clinical Evidence and Basic Mechanisms (2005, background): “This reduction in the expression of adhesion molecules and, as a consequence immune-cell content of atherosclerotic lesions, has been observed in animal models and in human tissue”