Anti-Inflammatory Effects of Statins: Clinical Evidence and Basic Mechanisms

By M. Jain, P. Ridker. Nature reviews. Drug discovery, 2005

938 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Surgery

View Paper: https://www.semanticscholar.org/paper/8746254da065146bc6d19851bdc1fa6a544a130c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Stefanie Dimmeler
2. A. Zeiher
3. C. Urbich

In Immunology

1. Mihai G. Netea
2. Stefanie Dimmeler
3. A. Zeiher

Citations in the corpus

• The role of TNF-alpha in chronic inflammatory conditions, intermediary metabolism, and cardiovascular risk. (2007, background): “Indeed, an anti-inflammatory therapy seems reasonable in the case of patients displaying markers of the metabolic syndrome, because statins and peroxisome proliferator-activated receptor g agonists have been proven to improve lipid and glucosemetabolic parameters using anti-inflammatory mechanisms (”
• CXCL10/IP-10 in Infectious Diseases Pathogenesis and Potential Therapeutic Implications (2011, neutral): “Very interestingly, various studies recently indicate that statins (Atovastatin) used for lowering blood cholesterol have antiinflammatory function and may contribute to modulation the immune system [105].”
• Macrophage Phenotype and Function in Different Stages of Atherosclerosis (2016, neutral): “Furthermore, some of the cardioprotective effects of statins may be because of their anti-inflammatory effects, particularly when administered soon after the onset of acute coronary syndromes.(89)”
• Adipose tissue dysfunction in obesity, diabetes, and vascular diseases. (2008, background): “Statins have anti-inflammatory properties which may point towards an influence of statins on adipocyte function.(118) Nevertheless, short-”
• Structure-based Systems Biology for Analyzing Off-target Binding (2011, background): “[8]) or discovered serendipitously but not rationally for a single molecule, for example, imatinib [9,10] and lipitor [11].”
• Atheroprotective communication between endothelial cells and smooth muscle cells through miRNAs (2012, background): “Moreover, we investigated other activators of KLF2 such as HMG-CoA reductase inhibitor”