Antimicrobial peptides of multicellular organisms

By M. Zasloff. Nature, 2002

8,294 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/05509d207766c7bac327e55ddca03212c48faca0

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In Immunology

In Microbiology

Citations in the corpus

Antimicrobial Peptides (2013, background): “In animals, AMPs are mostly found in the tissues and organs that are exposed to airborne pathogens; and are believed to be the first line of the innate immune defense [24,25] against”
Multifunctional cationic host defence peptides and their clinical applications (2011, neutral): “of defence against invading microbes [12, 35, 36, 120].”
LL-37, the only human member of the cathelicidin family of antimicrobial peptides. (2006, background): “In tissues that first make contact with intruders, antimicrobial peptides (AMPs) are released from precursor proteins [1,2].”
Studies on anticancer activities of antimicrobial peptides. (2008, background): “Although defensins have been isolated from many different species, α- and β-defensins of human origin remain the best studied [10,22,151].”
Antimicrobial Peptides: An Emerging Category of Therapeutic Agents (2016, background): “…of phospholipids in mammalian membranes, with the zwitterionic phospholipids being present in the outer leaflet, while phospholipids with negatively charged head groups, if present, are localized in the inner leaflet facing the cytoplasm (Zasloff, 2002; Yeaman and Yount, 2003; Lai and Gallo, 2009).”
Plectasin is a peptide antibiotic with therapeutic potential from a saprophytic fungus (2005, methodology): “The effect of treatment was evaluated in two different ways: (1) a reduction in peritoneal bacterial counts in actively treated as compared with untreated control mice, or (2) survival for up to seven days after active treatment as compared with untreated controls.”
Characteristics of meiofauna in extreme marine ecosystems: a review (2018, background): “These small antibiotic molecules rapidly eradicate or incapacitate pathogenic agents such as viruses, bacteria or fungi, attempting not only to invade but also to proliferate within multi-cellular eukaryotes (Zasloff 2002; Bulet et al. 2004; Maróti et al. 2011).”
Antibacterial peptides for therapeutic use: obstacles and realistic outlook. (2006, background): “Advantages of peptides over conventional antibiotics A major motivation for therapeutic peptide use is their diverse potential applications: they can be used as single antimicrobials, in combination with other antibiotics for a synergistic effect, or as immunomodulatory and/or endotoxin-neutralizing”
Antimicrobial peptides: an overview of a promising class of therapeutics (2007, background): “ganisms, and are found among all classes of life ranging from prokaryotes to humans [1, 2].”
Cutting Edge: 1,25-Dihydroxyvitamin D3 Is a Direct Inducer of Antimicrobial Peptide Gene Expression1 (2004, background): “bial peptides (2, 3) that can fend off bacterial and viral”