IL-33: an alarmin cytokine with crucial roles in innate immunity, inflammation and allergy.
By C. Cayrol, J. Girard. Current Opinion in Immunology, 2014
697 citations recorded by the source corpus.
IL-33 is a nuclear cytokine from the IL-1 family constitutively expressed in epithelial barrier tissues and lymphoid organs, which plays important roles in type-2 innate immunity and human asthma. Recent studies indicate that IL-33 induces production of large amounts of IL-5 and IL-13 by group 2 innate lymphoid cells (ILC2s), for initiation of allergic inflammation shortly after exposure to allergens or infection with parasites or viruses. IL-33 appears to function as an alarmin (alarm signal) rapidly released from producing cells upon cellular damage or cellular stress. In this review, we discuss the cellular sources, mode of action and regulation of IL-33, and we highlight its crucial roles in vivo with particular emphasis on results obtained using IL33-deficient mice.
Subfields: Immunology, Surgery
View Paper: https://www.semanticscholar.org/paper/0151d565477629082ed7c906439d55a071b8d61d
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Immunology
In Surgery
Citations in the corpus
- Activated Type 2 Innate Lymphoid Cells regulate Beige Fat Biogenesis (2014, positive): “In these scenarios, the release of epithelial cellderived cytokines IL-33, IL-25, and thymic stromal lymphopoietin (TSLP) results in the activation of ILC2s, which then secrete IL-5 and IL-13 to initiate type 2 immune responses (Cayrol and Girard, 2014; Licona-Limón et al., 2013).”