From Krebs to clinic: glutamine metabolism to cancer therapy

By B. Altman, Zachary E. Stine, C. V. Dang. Nature Reviews. Cancer, 2016

823 citations recorded by the source corpus.

Subfields: Biotechnology, Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/de8cb948b9a20cbc2b08aaa3ab33a563e18e60a5

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biotechnology

1. Guido Kroemer
2. Y. Fouad
3. C. Aanei

In Cancer Research

1. L. Galluzzi
2. Guido Kroemer
3. Y. Fouad
4. J. B. Pedro
5. P. Porporato
6. C. Aanei
7. N. Filigheddu

In Molecular Biology

1. L. Galluzzi
2. Guido Kroemer
3. J. B. Pedro
4. P. Porporato
5. N. Filigheddu
6. Y. Fouad
7. C. Aanei
8. Douglas R. Green

Citations in the corpus

• T Cell Dysfunction in Cancer (2018, neutral): “First, glutamine is essential for T cell activation and differentiation, but is also often depleted from the TME due to its use as primary fuel for tumor cells (Altman et al., 2016; Carr et al., 2010).”
• The Acidic Tumor Microenvironment as a Driver of Cancer. (2019, neutral): “A shift toward glutamine metabolism is a characteristic feature of cancer cells (71) and has been demonstrated in cancer cells in response to acidosis lasting 24 h or more (39, 45).”
• Glutamine Metabolism in Cancer: Understanding the Heterogeneity (2017, neutral): “The GLS and GLS2 proteins are highly homologous, and most reports indicate that both are localized to mitochondria [6,93,94].”
• Revisiting the Warburg effect: historical dogma versus current understanding (2020, neutral): “Cancer cells are also addicted to glutamine, mainly driven by the Myc oncogene (Altman et al. 2016).”
• Revisiting the hallmarks of cancer. (2017, positive): “Glutamine is also captured by the mitochondria and converted into glutamate; this may be utilized directly or further converted to α-ketoglutarate (α-KG) that could act as a glucose alternative to produce citrate or share in fatty acid synthesis under unfavorable conditions [145].”
• Understanding the intersections between metabolism and cancer biology (2017, neutral): “A requirement for glutamine metabolism has been observed in many cancer types (Altman et al., 2016), but both tissue of origin and genetics contribute to this phenotype (Yuneva et al., 2012).”
• Targeting Metabolism for Cancer Therapy (2017, neutral): “Glutamine metabolism is upregulated by various oncogenic signaling pathways (Altman et al., 2016).”
• Mitochondrial metabolism and cancer (2017, positive): “This involves not only increased uptake of glucose (a fraction of which is redirected to the pentose phosphate pathway (PPP) for nucleic acid synthesis and glutathione reduction) [70], but also the ability to process glutamine oxidatively (for energy production via the Krebs cycle and the ETC) or re”