Stem and progenitor cells in skeletal muscle development, maintenance, and therapy.

By B. Péault, Michael A. Rudnicki, Y. Torrente, G. Cossu, J. Tremblay, T. Partridge, E. Gussoni, L. Kunkel, J. Huard. Molecular Therapy, 2007

602 citations recorded by the source corpus.

Satellite cells are dormant progenitors located at the periphery of skeletal myofibers that can be triggered to proliferate for both self-renewal and differentiation into myogenic cells. In addition to anatomic location, satellite cells are typified by markers such as M-cadherin, Pax7, Myf5, and neural cell adhesion molecule-1. The Pax3 and Pax7 transcription factors play essential roles in the early specification, migration, and myogenic differentiation of satellite cells. In addition to muscle-committed satellite cells, multi-lineage stem cells encountered in embryonic, as well as adult, tissues exhibit myogenic potential in experimental conditions. These multi-lineage stem cells include side-population cells, muscle-derived stem cells (MDSCs), and mesoangioblasts. Although the ontogenic derivation, identity, and localization of these non-conventional myogenic cells remain elusive, recent results suggest their ultimate origin in blood vessel walls. Indeed, purified pericytes and endothelium-related cells demonstrate high myogenic potential in culture and in vivo. Allogeneic myoblasts transplanted into Duchenne muscular dystrophy (DMD) patients have been, in early trials, largely inefficient owing to immune rejection, rapid death, and limited intramuscular migration--all obstacles that are now being alleviated, at least in part, by more efficient immunosuppression and escalated cell doses. As an alternative to myoblast transplantation, stem cells such as mesoangioblasts and CD133+ progenitors administered through blood circulation have recently shown great potential to regenerate dystrophic muscle.

Subfields: Genetics, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/de6f692613d66a084006638d82c9acbeaa2255e0

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. T. Partridge
2. P. Zammit
3. Michael A. Rudnicki
4. F. Relaix
5. C. Bentzinger

In Molecular Biology

1. T. Partridge
2. S. Badylak
3. P. Zammit
4. Michael A. Rudnicki
5. F. Relaix
6. C. Bentzinger

In Surgery

1. T. Partridge
2. S. Badylak
3. P. Zammit
4. F. Relaix
5. Michael A. Rudnicki

Citations in the corpus

• A perivascular origin for mesenchymal stem cells in multiple human organs. (2008, positive): “Some of us have previously discovered in ‘‘preplate’’ cultures of skeletal muscle a similar population of muscle-derived stem cells (MDSCs) of unknown identity that regenerate myofibers more efficiently than committed satellite cells (Qu-Petersen et al., 2002; Péault et al., 2007).”
• An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration (2011, background): “…in the population of myofiber-associated satellite cells (Cerletti et al., 2008; Kuang et al., 2007) but also of contributions to muscle regeneration on transplantation of many different types of stem cell selected and characterized in vitro on the basis of surface markers (Peault et al., 2007).”