An absolute requirement for Pax7-positive satellite cells in acute injury-induced skeletal muscle regeneration

By Christoph Lepper, T. Partridge, C. Fan. Development, 2011

996 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/96f530a218caf08982c1204e09a13ec9e0df9ae8

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Citations in the corpus

Building muscle: molecular regulation of myogenesis. (2012, background): “However, when Pax7-expressing satellite cells are ablated by diphtheria toxin from adult muscle, no other cell type appears to replenish the satellite cell pool or repair the tissue following injury (Lepper et al. 2011).”
Satellite cells are essential for skeletal muscle regeneration: the cell on the edge returns centre stage (2012, methodology): “Here, we review how such sophisticated recombination-based technology has helped resolve some questions that are central to satellite cell biology, with a particular focus on the seminal observations that muscle regeneration fails after the genetic ablation of satellite cells (Lepper et al., 2011; M”
Satellite Cells and Skeletal Muscle Regeneration (2015, positive): “Moreover, as mentioned earlier, several ablation studies indicated that satellite cell depletion completely impairs muscle regeneration (see section on satellite cell and regeneration) (172,209,259,309).”
Pax7-expressing satellite cells are indispensable for adult skeletal muscle regeneration (2011, background): “…and complementary to our study involving the transplantation of satellite cells to effect a rescue of muscle regeneration, skeletal muscle lacking satellite cells failed to regenerate even after transplantation of the affected muscle into a normal recipient muscle bed (Lepper et al., 2011).”
Making muscle: skeletal myogenesis in vivo and in vitro (2017, background): “…in vitro In adult muscle, the pool of quiescent Pax7+ satellite cells is closely associated with the myofibers (reviewed by Brack and Rando, 2012; Dumont et al., 2015), an arrangement that aides muscle repair during regeneration (Lepper et al., 2011; Murphy et al., 2011; Sambasivan et al., 2011).”