The Tumor Microenvironment Innately Modulates Cancer Progression

By D. Hinshaw, L. Shevde. Cancer Research, 2019

2,491 citations recorded by the source corpus.

Cancer development and progression occurs in concert with alterations in the surrounding stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of various cytokines, chemokines, and other factors. This results in a reprogramming of the surrounding cells, enabling them to play a determinative role in tumor survival and progression. Immune cells are important constituents of the tumor stroma and critically take part in this process. Growing evidence suggests that the innate immune cells (macrophages, neutrophils, dendritic cells, innate lymphoid cells, myeloid-derived suppressor cells, and NK cells) as well as adaptive immune cells (T cells and B cells) contribute to tumor progression when present in the tumor microenvironment (TME). Crosstalk between cancer cells and the proximal immune cells ultimately results in an environment that fosters tumor growth and metastasis. Understanding the nature of this dialog will allow for improved therapeutics that simultaneously target multiple components of the TME, increasing the likelihood of favorable patient outcomes.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/1b798fac3af8053fc5413d14497bc91fc2eaeeef

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Citations in the corpus

• Ferroptosis in cancer: from molecular mechanisms to therapeutic strategies (2024, background): “314 The cytokine transforming growth factor β (TGF β ) is responsible for cancer-associated fi broblast (CAF) formation and the establishment of an immunosuppressive TME after tumorigenesis.”
• Natural killer cells in cancer biology and therapy (2020, background): “However, the specific role of NK cells remains controversial and largely depends on distinct cancer types [109].”