The soluble interleukin 6 receptor: mechanisms of production and implications in disease

By Simon A. Jones, S. Horiuchi, N. Topley, N. Yamamoto, G. Fuller. The FASEB Journal, 2001

676 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/de33c0805a16ac35bd9d2ac2d8af0832cd383532

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Citations in the corpus

IL-10, IL-6, and TNF-alpha: central factors in the altered cytokine network of uremia--the good, the bad, and the ugly. (2005, background): “They have been shown to be important regulators of IL-6 activity, and sIL-6R provides an important signaling pathway intimately involved in the transition between the early and late phase of the inflammatory response [37].”
Interleukin-6, a Major Cytokine in the Central Nervous System (2012, background): “The relevance of trans-signaling in vivo in a number of peripheral and CNS diseases is widely recognized [111, 149, 230-234], and not surprisingly therapeutic approaches aiming to counteract IL-6 effects not only focus in IL-6 membrane receptor [235-238] but also in IL-6/sIL-6R complex [13, 239-241]”
Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation. (2001, background): “This sIL-6R/IL-6 complex has United Kingdom the capacity to activate cells that do not normally respond 3 Department of Microbiology to IL-6 through interaction with the ubiquitously expressed Tokyo Medical and Dental University signal-transducing element for the IL-6 family of cytokines, Tokyo 113 ”
The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. (2001, background): “IL-6 also activates the Ras-Raf signaling cascade, which regulates phosphorylation of MAPK and ultimately activation of transcription factors such as CEBP (77).”
The inflammatory response to extracorporeal membrane oxygenation (ECMO): a review of the pathophysiology (2016, background): “Whilst promoting the acute phase reaction, expansion and activation of T-cells and the differentiation of B cells, IL-6 may also downregulate the expression of other pro-inflammatory cytokines, as well as up-regulate the expression of the anti-inflammatory cytokines [100].”
Interleukin‐6 biology is coordinated by membrane‐bound and soluble receptors: role in inflammation and cancer (2006, background): “By placing IL-6 trans-signaling within this inflammatory context, studies are now beginning to comprehend how IL-6 protects against septic shock and directs resolution of acute inflammation and conversely, elicits detrimental consequences in more progressive chronic diseases [60–65].”
Directing Transition from Innate to Acquired Immunity: Defining a Role for IL-61 (2005, background): “Therefore, to unlock the secrets of IL-6 bioactivity during inflammation, it has become essential to define the pathological regulation and contribution of sIL-6R (25).”
Role of interleukin-6 in cancer progression and therapeutic resistance (2016, background): “or CD126) and the other a small, extracellular, secretory soluble receptor (sIL-6R) [29].”