Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation.

By S. Hurst, T. S. Wilkinson, R. McLoughlin, Suzanne Jones, S. Horiuchi, N. Yamamoto, S. Rose‐John, G. Fuller, N. Topley, S. A. Jones. Immunity, 2001

850 citations recorded by the source corpus.

During acute inflammation, leukocyte recruitment is characterized by an initial infiltration of neutrophils, which are later replaced by a more sustained population of mononuclear cells. Based on both clinical and experimental evidence, we present a role for IL-6 and its soluble receptor (sIL-6R) in controlling this pattern of leukocyte recruitment during peritoneal inflammation. Liberation of sIL-6R from the initial neutrophil infiltrate acts as a regulator of CXC and CC chemokine expression, which contributes to a suppression of neutrophil recruitment and the concurrent attraction of mononuclear leukocytes. Soluble IL-6R-mediated signaling is therefore an important intermediary in the resolution of inflammation and supports transition between the early predominantly neutrophilic stage of an infection and the more sustained mononuclear cell influx.

Subfields: Immunology, Immunology and Allergy, Oncology

View Paper: https://www.semanticscholar.org/paper/0b376c5701a3ff168bda545cf99bde4fae1e54a7

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Citations in the corpus

Macrophage Cytokines: Involvement in Immunity and Infectious Diseases (2014, background): “IL-6 trans signaling also leads to recruitment of monocytes to the inflammation site (42), promotes the maintenance of Th17 cells, and inhibits T cell apoptosis and development of Tregs (43).”
Neutrophil cell surface receptors and their intracellular signal transduction pathways (2013, background): “Additional cytokines such as IL-4 [124,125], IL-6 [126–128] and IL-15 [129,130] are also involved in activation of neutrophils and the coordination of the inflammatory response.”
Phagocyte partnership during the onset and resolution of inflammation (2010, background): “As a consequence, endothelial cells upregulate the expression of CCL2 and VCAM1, which trigger the adhesion and emigration of classical monocyte”
Cytokines in Inflammatory Disease (2019, background): “IL-6 is essential in this so-called leukocyte switch [37].”
Interleukin-6, a Major Cytokine in the Central Nervous System (2012, background): “The relevance of trans-signaling in vivo in a number of peripheral and CNS diseases is widely recognized [111, 149, 230-234], and not surprisingly therapeutic approaches aiming to counteract IL-6 effects not only focus in IL-6 membrane receptor [235-238] but also in IL-6/sIL-6R complex [13, 239-241]”
Interleukin-6 and chronic inflammation (2006, background): “Expression of IL-6Rα is limited in humans to leucocyte and hepatocyte membranes [20,21], but it can be shed from the neutrophil membrane as a soluble form, which is found at high concentrations in neutrophil enriched inflammatory fluids [22].”