The pentose phosphate pathway and cancer
By K. Patra, N. Hay. TIBS -Trends in Biochemical Sciences. Regular ed, 2014
1,299 citations recorded by the source corpus.
The pentose phosphate pathway (PPP), which branches from glycolysis at the first committed step of glucose metabolism, is required for the synthesis of ribonucleotides and is a major source of NADPH. NADPH is required for and consumed during fatty acid synthesis and the scavenging of reactive oxygen species. Therefore, the PPP plays a pivotal role in helping glycolytic cancer cells to meet their anabolic demands and combat oxidative stress. Recently, several neoplastic lesions were shown to have evolved to facilitate the flux of glucose into the pentose phosphate pathway. This review summarizes the fundamental functions of the PPP, its regulation in cancer cells, and its importance in cancer cell metabolism and survival.
Subfields: Biotechnology, Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/de003c245d471ee37a957569ac5d107909f0cae6
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cancer Research
- Nikos Koundouros
- W. Marston Linehan
- M. Santoro
- R. Srinivasan
- G. Poulogiannis
- Huafeng Zhang
- Zhaoyong Li
- E. Panieri
In Molecular Biology
- Nikos Koundouros
- Hui Shen
- W. Marston Linehan
- Gordon B. Mills
- M. Santoro
- Rameen Beroukhim
- R. Srinivasan
- G. Poulogiannis
Citations in the corpus
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- Reprogramming of glucose, fatty acid and amino acid metabolism for cancer progression (2015, background): “However, oncoproteins, including PI3K, mTORC1 and K-ras, stimulate glycolysis and PPP [57, 61].”
- Reprogramming of fatty acid metabolism in cancer (2019, background): “AKT can indirectly promote NADPH production by activating the nuclear factor-like 2 (Nrf2) transcription factor,(20,86) leading to the transcription of genes involved in NADPH synthesis, including 6-phosphogluconate dehydrogenase (6PGD), glucose-6-phosphate dehydrogenase (G6PD) and malic enzyme 1 (M”
- The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma (2018, background): “High ribose metabolism gene expression was present in both ccRCC and CIMPRCC, with CIMP-RCC showing the greatest expression, likely due to the increased production of NADPH counteracting the cellular stress induced by the loss of fumarate hydratase in these tumors (Ooi et al., 2011; Patra and Hay, 2”