The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
By C. Ricketts, Aguirre A. de Cubas, Huihui Fan, Christof C. Smith, M. Lang, Ed Reznik, R. Bowlby, E. Gibb, Rehan Akbani, Rameen Beroukhim and 35 more. Cell Reports, 2018
731 citations recorded by the source corpus.
SUMMARY Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic subtypes, including 488 clear cell RCC, 274 papillary RCC, and 81 chromophobe RCC. Comprehensive genomic and phenotypic analysis of the RCC subtypes reveals distinctive features of each subtype that provide the foundation for the development of subtype-specific therapeutic and management strategies for patients affected with these cancers. Somatic alteration of BAP1, PBRM1, and PTEN and altered metabolic pathways correlated with subtype-specific decreased survival, while CDKN2A alteration, increased DNA hypermethylation, and increases in the immune-related Th2 gene expression signature correlated with decreased survival within all major histologic subtypes. CIMP-RCC demonstrated an increased immune signature, and a uniform and distinct metabolic expression pattern identified a subset of metabolically divergent (MD) ChRCC that associated with extremely poor survival.
Subfields: Cancer Research, Pulmonary and Respiratory Medicine
View Paper: https://www.semanticscholar.org/paper/d128af6cd3d6c9c2cabe5e8dfd90f1ff8e02099f
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In Cancer Research
Citations in the corpus
- Cell-of-Origin Patterns Dominate the Molecular Classification of 10,000 Tumors from 33 Types of Cancer (2018, background): “Consequently, these four major cell-of-origin patterns are the subject of separate in-depth reports detailing their distinguishing genomic and molecular features (Berger et al., 2018; Campbell et al., 2018; Liu et al., 2018; Malta et al., 2018; Ricketts et al., 2018).”