The Gene Ontology's Reference Genome Project: A Unified Framework for Functional Annotation across Species
By Pascale Gaudet, R. Chisholm, T. Berardini, E. Dimmer, S. Engel, P. Fey, David P. Hill, D. Howe, James C. Hu, Rachael P. Huntley and 21 more. 2009
158 citations recorded by the source corpus.
The Gene Ontology (GO) is a collaborative effort that provides structured vocabularies for annotating the molecular function, biological role, and cellular location of gene products in a highly systematic way and in a species-neutral manner with the aim of unifying the representation of gene function across different organisms. Each contributing member of the GO Consortium independently associates GO terms to gene products from the organism(s) they are annotating. Here we introduce the Reference Genome project, which brings together those independent efforts into a unified framework based on the evolutionary relationships between genes in these different organisms. The Reference Genome project has two primary goals: to increase the depth and breadth of annotations for genes in each of the organisms in the project, and to create data sets and tools that enable other genome annotation efforts to infer GO annotations for homologous genes in their organisms. In addition, the project has several important incidental benefits, such as increasing annotation consistency across genome databases, and providing important improvements to the GO's logical structure and biological content.
Subfields: Molecular Biology
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In Molecular Biology
- Huaiyu Mi
- Anushya Muruganujan
- Paul D. Thomas
- Dustin Ebert
- Tremayne Mushayahama
- Laurent-Philippe Albou
- Lorrie Boucher
- Teresa Reguly
Citations in the corpus
- A semi-automated genome annotation comparison and integration scheme (2013, background): “Researchers attempted to solve this issue by introducing controlled vocabularies, such as Gene Ontology (GO) [12].”
- The BioGRID Interaction Database: 2011 update (2010, background): “A cross-species curation drive on the Wnt pathway, which is being comprehensively annotated by the GO Reference Genome Project (12), is underway by BioGRID and WormBase curators.”
- PANTHER: Making genome‐scale phylogenetics accessible to all (2021, methodology): “23 Rather than utilizing a small subset of GO terms for annotation of trees — in essence, representing only the largest leaps in protein function evolution — we developed a method and software infrastructure for annotating the evolutionary gain and loss of a function described by any GO term on any…”