Mind bomb is a ubiquitin ligase that is essential for efficient activation of Notch signaling by Delta.

By Motoyuki Itoh, Cheol‐Hee Kim, Gregory R. Palardy, T. Oda, Yun-Jin Jiang, Donovan T. Maust, Sang-Yeob Yeo, K. Lorick, Gavin J. Wright, L. Ariza-McNaughton and 4 more. Developmental Cell, 2003

828 citations recorded by the source corpus.

Subfields: Cell Biology, Developmental Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/dd4e2a5b73ba6fc58e98dceb8a36d5b409b1024b

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Citations in the corpus

Notch signaling: control of cell communication and cell fate (2004, background): “Recent studies show that the effect of Neuralized and Mindbomb is actually to increase the ability of Delta to activate Notch signaling in neighboring cells (Itoh et al., 2003) (reviewed by Le Borgne and Schweisguth, 2003).”
Notch signaling: simplicity in design, versatility in function (2011, background): “Mind bomb (Mib) (Itoh et al., 2003) and Neuralized (Neur) (Yeh et al.”
Notch signaling: the core pathway and its posttranslational regulation. (2009, background): “Moreover, DSL ligands are detected in intracellular vesicles in Drosophila and mammalian cells (Itoh et al., 2003; Kooh et al., 1993).”
Developmental genetics of vertebrate glial–cell specification (2010, background): “Progenitors in the pMN domain contribute solely to motor neuron production in NOTCH mutants, whereas forced expression of activated NOTCH1 blocks neurogenesis and results in excess OPC”
Development and Evolution of the Human Neocortex (2011, neutral): “, 2008), an E3 ubiquitin ligase that is essential for generating functional Notch ligands (Itoh et al., 2003; Koo et al., 2005).”