Reactive oxygen species (ROS) and reactive nitrogen species (RNS) generation by silica in inflammation and fibrosis.

By B. Fubini, A. Hubbard. Free Radical Biology & Medicine, 2003

869 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/dc65c4fe8f83933f24c52f85aa2dcf7960a250d1

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Citations in the corpus

Reactive oxygen species and mitochondria: A nexus of cellular homeostasis (2015, background): “Shared mechanisms include a drop in intracellular Kþ concentration [109,110], increases in Ca2þ concentration [111–114], and lysosomal disruption [103,115,116].”
Mesoporous silica nanoparticles in medicine--recent advances. (2013, background): “A lot of studies have been focusing on the generation of reactive oxygen species (ROS) upon cellular uptake of crystalline silica polymorphs, especially in relation to exposure through inhalation and subsequent potential development of, for example, silicosis or lung cancer as recently reviewed [104”
Integrating mechanisms of pulmonary fibrosis (2011, background): “Lung fibrosis can also develop after viral infections and after exposure to radiotherapy, chemotherapeutic drugs, and aerosolized environmental toxins (Denham and Hauer-Jensen, 2002; Kelly et al., 2002; Fubini and Hubbard, 2003; Chen and Stubbe, 2005).”
Comparative eco-toxicity of nanoscale TiO2, SiO2, and ZnO water suspensions. (2006, background): “It is documented that these three compounds are photosensitive and produce reactive oxygen species (ROS) in the presence of light (Yeber et al., 2000; Fubini and Hubbard, 2003; Kubo et al., 2005).”
Preventing or reducing late side effects of radiation therapy: radiobiology meets molecular pathology (2006, background): “There is direct evidence that the SOD enzymes have an important role in the molecular pathology of fibrosi”
Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity (2013, background): “Free radicals are either directly bound to the NP surface or may be generated as free entities in an aqueous suspension [17].”
Redox Regulation of NLRP3 Inflammasomes: ROS as Trigger or Effector? (2015, unknown): “Interestingly, incomplete phagocytosis of crystalline particulates by phagocytic cells such as macrophages is a source of ROS as well as reactive nitrogen species (41).”
Nanomaterial cytotoxicity is composition, size, and cell type dependent (2010, background): “In addition, cells exposed to silicon oxide (SiO2) nanoparticles show caspase activation and cell death via apoptosis but the suggested pathways leading to apoptosis differed [23-25].”
The inflammasomes: guardians of the body. (2009, background): “ROS production occurs quickly upon exposure of macrophages with silica or asbestos dust (127, 128, 147, 148).”
Copper oxide nanomaterials: Synthesis, characterization and structure-specific antibacterial performance (2015, background): “The ROS are either directly bound to theNMs surface ormay be generated as free entities in an aqueous suspension [61].”
Silica crystals and aluminum salts mediate NALP-3 inflammasome activation via phagosomal destabilization (2008, background): “Silica crystals trigger the production of reactive oxygen species in macrophages, events reported to be linked to disease pathology in silica-induced inflammatio”