POT1 as a terminal transducer of TRF1 telomere length control

By D. Loayza, T. de Lange. Nature, 2003

751 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology, Plant Science

View Paper: https://www.semanticscholar.org/paper/dc51a7e1c7ebdf14d95caf1a42aeabc5d357bb87

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. J. Karlseder
2. de Lange
3. Wilhelm Palm
4. D. Hockemeyer
5. T. de Lange
6. Agnel Sfeir
7. Roderick J. O’Sullivan
8. Sheila L. MacRae

In Physiology

1. J. Karlseder
2. de Lange
3. T. de Lange
4. Wilhelm Palm
5. D. Hockemeyer
6. Roderick J. O’Sullivan
7. Agnel Sfeir
8. Sheila L. MacRae

In Plant Science

1. T. de Lange
2. J. Karlseder
3. de Lange

Citations in the corpus

• How shelterin protects mammalian telomeres. (2008, background): “Diminished loading of POT1 or replacement of the endogenous POT1 with a mutant that lacks the DNAbinding domain leads to telomerase-dependent telomere elongation (122, 204).”
• How shelterin solves the telomere end-protection problem. (2010, background): “The complex contains a third DNAbinding protein, POT1, that has two oligosaccharide/ oligonucleotide binding (OB) folds that associate with single-strand TTAGGG repeats (Baumann and Cech 2001; Loayza and de Lange 2003; Lei et al. 2004).”
• SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin (2008, neutral): “To investigate this possibility, we first examined whether SIRT6 associates with telomeres during S phase by telomere chromatin immunoprecipitation (T-ChIP) 18 .”
• Shelterin: the protein complex that shapes and safeguards human telomeres. (2005, positive): “In this setting, telomerase generates very long telomeres that have lost the ability to inhibit the enzyme even though their shelterin load steadily increases (Loayza and de Lange 2003).”
• Telomere protection by mammalian Pot1 requires interaction with Tpp1 (2007, background): “Owing to these interactions, Pot1 not only interacts with single-stranded telomeric DNA but also accumulates along the duplex telomeric repeat arra”
• Mammalian telomeres resemble fragile sites and require TRF1 for efficient replication (2009, methodology): “IP of telomeric chromatin was performed as previously described ( Loayza and de Lange, 2003 ) and analyzed by dot-blotting using a TTAGGG repeat probe”
• Telomeres: protecting chromosomes against genome instability (2010, background): “POT1 contributes to telomere protection by binding to the G-overhang and by the suppression of ATM- and RAD3-related protein ( ATR )-dependent DDR pathway”