The multilayered complexity of ceRNA crosstalk and competition

By Yvonne Tay, Johannes Rinn, P. Pandolfi. Nature, 2014

3,595 citations recorded by the source corpus.

Recent reports have described an intricate interplay among diverse RNA species, including protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs, pseudogenes and circular RNAs. These RNA transcripts act as competing endogenous RNAs (ceRNAs) or natural microRNA sponges — they communicate with and co-regulate each other by competing for binding to shared microRNAs, a family of small non-coding RNAs that are important post-transcriptional regulators of gene expression. Understanding this novel RNA crosstalk will lead to significant insight into gene regulatory networks and have implications in human development and disease.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/63bd3fdf3d53fd2208f11dea77d397f3247eeaf9

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. Igor Ulitsky
2. Yvonne Tay
3. J. J. Chan

In Molecular Biology

1. Igor Ulitsky
2. Yvonne Tay
3. Y. Yarden
4. J. J. Chan
5. M. Lacouture

Citations in the corpus

• The Landscape of long non-coding RNA classification (2015, neutral): “Another example is Competing endogenous RNAs (ceRNAs) [109].”
• Circular RNAs are long-lived and display only minimal early alterations in response to a growth factor (2015, background): “The well-established microRNA sponging function of two circular RNAs, namely CDR1as and Sry, spawned models attributing to additional RNA circles the ability to decoy multiple copies of the same microRNA (25,26).”
• Noncoding RNA:RNA Regulatory Networks in Cancer (2018, background): “The prominent classes of lncRNAs share a common functionality in their ability to shape gene expression by titrating miRNAs in a phenomenon known as the competing endogenous RNA (ceRNA) hypothesis [18,19].”
• The Cellular and Molecular Landscapes of the Developing Human Central Nervous System (2016, neutral): “On the other hand, long non-coding RNAs (lncRNAs) and pseudogenes can act as regulators of transcription (Morris and Mattick, 2014), compete with endogenous RNAs, or act as miRNA sponges to post-transcriptionally regulate the levels and dynamics of protein-coding transcripts (Tay et al., 2014).”
• Circular RNAs: Promising Biomarkers for Human Diseases (2018, background): “CircRNAs contain plenty of miRNA response elements (MREs) that allow them to competitively bind to miRNAs, leading to decreasing of the functional miRNA molecules and subsequent upregulation of target miRNAs [6,16].”
• The bioinformatics toolbox for circRNA discovery and analysis (2020, background): “CircRNA can act as a miRNA sponge or competing endogenous RNA (ceRNA) which competes for miRNA pairing with other RNAs [9, 28, 29].”