A ceRNA hypothesis: the Rosetta stone of a hidden RNA language?
By L. Salmena, L. Poliseno, Yvonne Tay, Lev M. Kats, P. Pandolfi. Cell, 2011
6,724 citations recorded by the source corpus.
Summary Here we present a unifying hypothesis about how messenger RNAs, transcribed pseudogenes, and long non-coding RNAs “talk” to each other using microRNA response elements (MREs) as letters of a new language. We propose that this “competing endogenous RNA” (ceRNA) activity forms a large-scale regulatory network across the transcriptome, greatly expanding the functional genetic information in the human genome and playing important roles in pathological conditions, such as cancer.
Subfields: Cancer Research, Molecular Biology
View Paper: https://www.semanticscholar.org/paper/fa71d3a9c4eb17cbce321dd80ff17585bf5a74b7
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In Cancer Research
- Xing Chen
- Zhuhong You
- Yvonne Tay
- Guiying Yan
- Isidore Rigoutsos
- Vikram Agarwal
- Chenggang Clarence Yan
- Xu Zhang
In Molecular Biology
- Xing Chen
- Zhuhong You
- Guido Kroemer
- Yvonne Tay
- L. Galluzzi
- Guiying Yan
- P. Pandolfi
- Chenggang Clarence Yan
Citations in the corpus
- Metazoan MicroRNAs (2018, background): “…and accessible for the target search (Elkayam et al., 2012; Nakanishi et al., 2012; Schirle and MacRae, 2012) (Figure 6A, step 1), and single-molecule analyses demonstrate that this sub-seed segment is indeed most critical for target association (Chandradoss et al., 2015; Salomon et al., 2015).”
- Mechanism of action of conventional and targeted anticancer therapies: reinstating immunosurveillance. (2013, background): “…to anthracyclines (e.g., doxorubicin, mitoxantrone), oxaliplatin, and mafosfamide, the active metabolite of cyclophosphamide (Obeid et al., 2007; Schiavoni et al., 2011; Tesniere et al., 2010) Conversely, antineoplastic agents that fail to induce CRT exposure (e.g., cisplatin, mitomycin C) are…”
- Long non-coding RNAs: a new frontier in the study of human diseases. (2013, background): “hypothesized that these ceRNAs, including protein-coding genes, pseudogenes and long noncoding RNAs, can communicate with each other through their ability to compete for microRNA binding [97].”
- Noncoding RNA:RNA Regulatory Networks in Cancer (2018, background): “Since each miRNA is able to target hundreds or thousands of genes, and similarly, multiple miRNAs can simultaneously target a single RNA transcript with many MREs, transcripts containing MREs for the same miRNA can coregulate one another (Figure 2A) [18].”