Inflammasomes: Mechanism of Action, Role in Disease, and Therapeutics

By Haitao Guo, Justin B. Callaway, J. Ting. Nature Medicine, 2015

3,031 citations recorded by the source corpus.

The inflammasomes are innate immune system receptors and sensors that regulate the activation of caspase-1 and induce inflammation in response to infectious microbes and molecules derived from host proteins. They have been implicated in a host of inflammatory disorders. Recent developments have greatly enhanced our understanding of the molecular mechanisms by which different inflammasomes are activated. Additionally, increasing evidence in mouse models, supported by human data, strongly implicates an involvement of the inflammasome in the initiation or progression of diseases with a high impact on public health, such as metabolic disorders and neurodegenerative diseases. Finally, recent developments pointing toward promising therapeutics that target inflammasome activity in inflammatory diseases have been reported. This review will focus on these three areas of inflammasome research.

Subfields: Epidemiology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/dc178c074e7d33370985ee94b4d7a22613af164a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. A. Benito-Vicente
2. A. Larrea-Sebal
3. U. Galicia-Garcia
4. M. Lamkanfi
5. César Martín
6. E. Latz

In Genetics

1. M. Lamkanfi

In Molecular Biology

1. M. Lamkanfi
2. Yuan He
3. G. van Loo
4. A. Grebe
5. M. Maffei
6. E. Latz
7. Florian Hoss
8. T. Kanneganti

Citations in the corpus

• Pathophysiology of Atherosclerosis (2022, background): “Inflammasomes are cytosolic multiprotein complexes of the innate immune system responsible for the activation of inflammatory pathways [162].”
• Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome. (2016, background): “…inflammasome is therefore involved in the pathogenesis of several inflammatory disorders, including type-2 diabetes (T2D), atherosclerosis, gout, and Alzheimer’s disease, suggesting that this activation needs to be tightly controlled (Guo et al., 2015; Schroder et al., 2010; Strowig et al., 2012).”
• NF-κB signaling in inflammation (2017, neutral): “59 NLRP3 inflammasome is currently the most extensively studied inflammasome, which is composed of NLRP3, ASC and pro-caspase 1, as well as an essential regulatory protein, NIMA-related kinase 7 (NEK7).”
• Inflammasomes in neuroinflammatory and neurodegenerative diseases (2019, background): “Therefore, modulating the activity of specific inflammasome sensors and cell type-specific inflammasome targeting with small molecules will be vital in this context and may have better potential as therapies to treat patients that suffer from neurodegenerative diseases (Guo et al, 2015).”
• The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation (2019, background): “The NLRP3 inflammasome is critical for host immune defenses against bacterial, fungal, and viral infections [20–23]; however, it has been linked to the pathogenesis of several inflammatory disorders when dysregulated, including cryopyrin-associated periodic syndromes (CAPS), Alzheimer’s disease, dia”
• Human Monocytes Engage an Alternative Inflammasome Pathway. (2016, neutral): “, via Toll-like receptor (TLR) signaling, whereas a second signal (signal 2) is recognized in order to activate the inflammasome (Guo et al., 2015; Lamkanfi and Dixit, 2014; Latz et al., 2013; Wen et al., 2013).”