Prokaryotic origin of the actin cytoskeleton

By F. V. D. Ent, L. Amos, J. Löwe. Nature, 2001

808 citations recorded by the source corpus.

Subfields: Genetics, Materials Chemistry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/dc0c66a3c57c0a0429b5530649e47875cac73f49

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In Genetics

In Materials Chemistry

Eugene V. Koonin

In Molecular Biology

Citations in the corpus

Bacterial Cell Wall Synthesis: New Insights from Localization Studies (2005, background): “The second paper showed that MreB from Thermotoga maritima has biochemical properties similar to those of actin and a crystal structure that closely resembles that of actin (189).”
Toxin-antitoxin systems in bacteria and archaea. (2011, background): “MreB is required for maintenance of the typical rod shape of cells, and assembles into a helical structure that coils along the cell length (48, 104).”
The phagotrophic origin of eukaryotes and phylogenetic classification of Protozoa. (2002, background): “A much better candidate for an actin ancestor is MreB, a shape-determining protein of rod-shaped eubacteria that forms similar filaments that associate with membranes (van den Ent et al., 2001).”
Bacterial shape (2003, background): “…helical pitch of Mbl polymers changes with cell length and protein concentration (Carballido-Lopez and Errington, 2003), and MreB filaments created in vitro have variable curvatures that differ from the innate diameter of the bacteria from which the proteins originate (van den Ent et al ., 2001).”
Orthologs, Paralogs, and Evolutionary Genomics 1 (2005, background): “An analogous situation is seen with the other signature proteins of eukaryotes, actins, and ubiquitins, whose apparent prokaryotic orthologs have completely different functions and dramatically differ in sequence (1, 92, 96).”
Actin binding proteins: regulation of cytoskeletal microfilaments. (2003, background): “Amino acid sequence homology to actin is limited to 15% (289), and although its overall size and shape strongly resemble actin, there are differences.”
Actin Structure and Function (2011, neutral): “The bacterial actin homology MreB forms filaments (53) that are single stranded and straight.”